Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running
Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running
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DOI：
10.1037/0735-7044.117.5.1006
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发表时间：
2003-10-01
影响因子：
1.9
通讯作者：
Gage, FH
中科院分区：
文献类型：
--
作者：
Rhodes, JS;van Praag, H;Gage, FH
海马体对获得新记忆很重要。它也是成年哺乳动物大脑中少数能够产生新神经细胞的区域之一。作者在选择性饲养的高水平滚轮跑步小鼠（S小鼠）中测试了自愿运动增加神经发生和增强空间学习能力的假设。雌性S小鼠和远交系对照(C)小鼠分别在有滚轮和无滚轮的环境中饲养40 d。用5-溴脱氧尿苷标记分裂细胞。Morris水迷宫测试空间学习能力。C组跑步者在跑步距离和新细胞数量之间表现出很强的正相关，学习能力也有所提高。在跑步者中，神经发生增加到很高的水平，达到了一个平台，但在学习方面没有任何改善。这是第一个证明神经发生可以在没有学习增强的情况下发生的证据。作者提出了神经发生在运动行为控制中的另一种功能。
The hippocampus is important for the acquisition of new memories. It is also one of the few regions in the adult mammalian brain that can generate new nerve cells. The authors tested the hypothesis that voluntary exercise increases neurogenesis and enhances spatial learning in mice selectively bred for high levels of wheel running (S mice). Female S mice and outbred control (C) mice were housed with and without running wheels for 40 days. 5-Bromodeoxyuridine was used to label dividing cells. The Morris water maze was used to measure spatial learning. C runners showed a strong positive correlation between running distance and new cell number, as well as improved learning. In S runners, neurogenesis increased to high levels that reached a plateau, but no improvement in learning occurred. This is the first evidence that neurogenesis can occur without learning enhancement. The authors propose an alternative function of neurogenesis in the control of motor behavior.