Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258.
Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258.
复制标题
DOI：
10.1093/ofid/ofv213
复制
发表时间：
2016-01
影响因子：
4.2
通讯作者：
Marchaim D
中科院分区：
文献类型：
--
作者：
Dhar S;Martin ET;Lephart PR;McRoberts JP;Chopra T;Burger TT;Tal-Jasper R;Hayakawa K;Ofer-Friedman H;Lazarovitch T;Zaidenstein R;Perez F;Bonomo RA;Kaye KS;Marchaim D
经多位点序列分型（MLST）鉴定为序列型（ST） 258的耐碳青霉烯肺炎克雷伯菌（CRKP）“高风险”克隆已在全球传播。随着CRE大流行的分子流行病学不断发展，非st258菌株的临床影响尚不明确。基于MLST菌株对CRKP进行流行病学调查。68例CRKP患者中，ST258 61例，非ST258 7例。肺炎克雷伯菌ST258菌株与blaKPC的产生和对更多抗菌素的耐药性显著相关。临床结果无差异。基于这一分析，我们不能仅仅依靠blaKPC的存在来诊断CRKP。
A “high risk” clone of carbapenem-resistant Klebsiella pneumoniae (CRKP) identified by multilocus sequence typing (MLST) as sequence type (ST) 258 has disseminated worldwide. As the molecular epidemiology of the CRE pandemic continues to evolve, the clinical impact of non-ST258 strains is less well defined. We conducted an epidemiological investigation of CRKP based on strains MLST. Among 68 CRKP patients, 61 were ST258 and 7 belonged to non-ST258. Klebsiella pneumoniae ST258 strains were significantly associated with blaKPC production and with resistance to an increased number of antimicrobials. Clinical outcomes were not different. Based on this analysis, one cannot rely solely on the presence of blaKPC in order to diagnose CRKP.