Copper-catalyzed arylation and alkenylation of polyfluoroarene C-H bonds
Copper-catalyzed arylation and alkenylation of polyfluoroarene C-H bonds
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DOI：
10.1021/ja077862l
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发表时间：
2008-01-30
影响因子：
15
通讯作者：
Daugulis, Olafs
中科院分区：
文献类型：
--
作者：
Do, Hien-Quang;Daugulis, Olafs
开发了一种有效的铜催化的多氟芳烃的芳基化、烯基化和苄基化方法。在芳环上含有两个或更多个氟取代基的芳烃可以有效地官能化。通过使用碘化铜催化剂、菲咯啉配体、芳基溴或芳基碘偶联配偶体和DMF或DMF/二甲苯混合溶剂的组合获得最佳结果。
An efficient, copper-catalyzed method for the arylation, alkenylation, and benzylation of polyfluoroarenes has been developed. Arenes containing two or more fluorine substituents on the aromatic ring can be efficiently functionalized. The best results are obtained by using a combination of copper iodide catalyst, phenanthroline ligand, aryl bromide or aryl iodide coupling partner, and DMF or DMF/xylene mixed solvent.