Comparison of Diagnostic Cytomorphology of Natural Killer/T-Cell Lymphoma (Nasal Type) in Conventional Smears, Liquid-Based Preparations, and Histopathology.
Comparison of Diagnostic Cytomorphology of Natural Killer/T-Cell Lymphoma (Nasal Type) in Conventional Smears, Liquid-Based Preparations, and Histopathology.
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DOI：
10.1155/2018/6264810
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发表时间：
2018
影响因子：
0.6
通讯作者：
Tsai HC
中科院分区：
文献类型：
--
作者：
Liu CY;Tsai HC
自然杀伤（NK）/T细胞淋巴瘤在2008年和2016年世界卫生组织（WHO）分类中正式称为鼻型结NK/T细胞淋巴瘤（ENKTCL）。鼻型NK/T细胞淋巴瘤是一种罕见但临床上重要的淋巴系统肿瘤。它是与EB病毒（EBV）相关的淋巴结淋巴瘤的主要类型。NK/T细胞淋巴瘤的特点是广泛的细胞形态学谱。NK/T细胞淋巴瘤的细胞学检查结果可能非常细微，很容易被忽视。在这里，我们报告一个NK/T细胞淋巴瘤的情况下，涉及鼻腔鼻窦区淋巴结受累。进行颈部淋巴结细针抽吸和鼻粘膜打孔活检。NK/T细胞淋巴瘤的诊断是根据病理和免疫组化分析，以及EBV编码的mRNA（EBER）的原位杂交确认。本病例报告强调了在疑似病例中及时进行临床病理评估的重要性。本文对NK/T细胞淋巴瘤的细胞形态学特征进行了比较。
Natural killer (NK)/T-cell lymphoma is formally referred to as extranodal NK/T-cell lymphoma, nasal type (ENKTCL), in the 2008 and 2016 World Health Organization (WHO) classifications. NK/T-cell lymphoma, nasal type, is a rare but clinically important lymphoid neoplasm. It is the predominant type of extranodal lymphoma associated with the Epstein–Barr virus (EBV). NK/T-cell lymphoma is marked by a wide cytomorphological spectrum. The cytological findings may be so subtle that NK/T-cell lymphoma could possibly be easily overlooked. Here, we report a case of NK/T-cell lymphoma involving the sinonasal region with lymph node involvement. Fine needle aspiration of the neck lymph node and punch biopsy of the nasal mucosa were performed. The diagnosis of NK/T-cell lymphoma was confirmed based on pathological and immunohistochemical analyses, as well as in situ hybridization for EBV-encoded mRNA (EBER). The present case report underlines the importance of prompt clinicopathological assessment in suspected cases. The comparison of cytomorphologic features of NK/T-cell lymphoma in various specimens is presented.