HUD, A PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGEN, CONTAINS RNA-BINDING DOMAINS AND IS HOMOLOGOUS TO ELAV AND SEX-LETHAL
HUD, A PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGEN, CONTAINS RNA-BINDING DOMAINS AND IS HOMOLOGOUS TO ELAV AND SEX-LETHAL
复制标题
DOI：
10.1016/0092-8674(91)90184-z
复制
发表时间：
1991-10-18
期刊：
影响因子：
64.5
通讯作者：
FURNEAUX, HM
中科院分区：
文献类型：
--
作者：
SZABO, A;DALMAU, J;FURNEAUX, HM
通过筛选lambda小脑表达文库，分离出抗体相关的副肿瘤性脑脊髓炎患者血清中识别的神经元抗原（HuD）。重组抗原为这种与小细胞肺癌相关的罕见疾病提供了明确的检测方法。重组抗原已被用于鉴定抗体相关的副肿瘤性脑脊髓炎和感觉神经病变患者肿瘤和受累脑组织中的特异性浸润淋巴细胞。HuD mRNA在脑组织中独特表达。HuD蛋白与果蝇蛋白Elav和性致死蛋白具有显著的同源性，可能在神经元特异性RNA加工中发挥作用。
A neuronal antigen (HuD) recognized by the sera of patients with antibody-associated paraneoplastic encephalomyelitis has been isolated by screening a lambda cerebellar expression library. The recombinant antigen provides an unambiguous assay for this rare condition associated with small cell lung cancer. The recombinant antigen has been used to identify specific infiltrating lymphocytes in tumors and affected brain tissues of patients with antibody-associated paraneoplastic encephalomyelitis and sensory neuronopathy. HuD mRNA is uniquely expressed in brain tissue. The HuD protein shows a remarkable homology to the Drosophila proteins Elav and Sex-lethal and is likely to play a role in neuron-specific RNA processing.