Aldicarb poisoning
Aldicarb poisoning
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DOI：
10.1191/096032700672133218
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发表时间：
2000-12
影响因子：
2.8
通讯作者：
C. Ragoucy-Sengler;A. Tracqui;'. Chavonnet;JB Daijardin;Simonetti;P. Kintz;Pileirel
中科院分区：
文献类型：
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作者：
C. Ragoucy-Sengler;A. Tracqui;'. Chavonnet;JB Daijardin;Simonetti;P. Kintz;Pileirel
涕灭威（2乙基-2（甲硫基）丙醛o-[（甲氨基）羰基]肟）是一种1965年以来生产的农药。这种氨基甲酸酯以商品名Temiks出售，用作杀虫剂和杀线虫剂。环境保护局将涕灭威归为毒性最高的一类，并对其交付和使用进行了严格控制。在巴西和加勒比岛屿，涕灭威被非法用作家庭灭鼠剂，具有广泛的中毒风险。本研究首次对涕灭威中毒情况进行了回顾，并结合临床和分析结果进行了分析。并对肟化处理进行了讨论。18名有胆碱能症状的病人被急诊室收治，2名死者有涕灭威中毒史，他们被纳入研究。作为农业工人，他们中只有两人可以合法使用Temikg。70%的病人由紧急流动股管理。血清胆碱酯酶活性始终低于正常范围的30%，涕灭威经液相色谱分离后，通过紫外光谱和保留时间进行鉴定。最常见的毒蕈碱效应是腹泻，主要的烟碱体征是肌颤，近半数中毒患者有中枢神经系统（CNS）抑制（格拉斯哥昏迷评分低于8分）。4例患者出现严重传导异常，其中2例死亡。这些结果表明，涕灭威中毒总是严重的。肟处理没有产生副作用，当涉及的农药未知时，应推荐使用。应采取有效措施，杜绝涕灭威的非法使用。
Aldicarb (2 ethyl-2 (methylthio) propanal o-[(methlamino)-carbonyl] oxime) is a pesticide manufactured since 1965. This carbamate ester is sold under the tradename, Temiks, and is used as insecticide and nematicide. The Environmental Protection Agency has classified aldicarb in the highest toxicity category and has defined a strict control for its delivery and use. In Brazil and the Caribbean island, aldicarb is illegally used as a household rodenticide with a widespread risk of poisoning. Our study presents the first review of aldicarb poisoning circumstances associated with cliical and analytical findings. Moreover, the oxime treament is discussed. Eighteen patients with cholinergic symptoms admitted to the Emergency Unit and two deceased with a history of aldicarb poisoning were included in the study. As agricultural workers, only two of them could legally use Temikg. Seventy percent of the patients was managed by the Emergency Mobil Unit. Serum cholinesterase activity was always lower than 30% of the normal range and aldicarb was identified by UV spectra and retention time after liquid chromatogrphy separation. The most common muscarinic effect was diarrhea, the main nicotinic sign fasciculation and almost half of the poisoned patients had central nervous system (CNS) depression (Glasgow Coma Score lower than 8). Four patients had serious conduction abnoralities and two of them died. These results suggest that aldicarb intoxication is always severe. Oxime treatment did not produce side effects and should be recommended whenever the pesticide involved is unknown. Effective measures should be implemented to stamp out the illicit use of aldicarb.