Orthostatic blood pressure reduction as a possible explanation for memory deficits in dialysis patients
Orthostatic blood pressure reduction as a possible explanation for memory deficits in dialysis patients
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DOI：
10.1038/s41440-019-0236-4
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发表时间：
2019-07-01
影响因子：
5.4
通讯作者：
Yang, Junwei
中科院分区：
文献类型：
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作者：
Liu, Wenjin;Wang, Lulu;Yang, Junwei
认知障碍在慢性肾脏病（CKD）患者中普遍存在，但其潜在机制尚不清楚。在这里，我们测试的假设，夸大直立位血压降低介导的影响，肾功能衰竭的全球认知和记忆。共招募了160名研究受试者，包括80名透析患者和80名对照。使用蒙特利尔认知评估（莫卡）评估整体认知，使用听觉言语学习测试（AVLT）评估情景记忆。通过心率变异性分析，通过低频/高频比值（LF/HF）评估自主神经功能。与对照组相比，透析患者的莫卡和AVLT评分（包括学习记忆、短回忆记忆和延迟回忆记忆）显著降低（均p < 0.001）。他们还表现出过度的直立性收缩压降低（所有p
Cognitive impairment is prevalent in patients with chronic kidney disease (CKD), but its underlying mechanisms are obscure. Here, we test the hypothesis that exaggerated orthostatic blood pressure reduction mediates the effects of renal failure on global cognition and memory. A total of 160 study subjects were recruited, including 80 dialysis patients and 80 controls. Global cognition was evaluated using the Montreal Cognitive Assessment (MoCA), and episodic memory was evaluated using the auditory verbal learning test (AVLT). Autonomic function was evaluated via the low-frequency to high-frequency ratio (LF/HF) through heart rate variability analysis. Compared with the controls, the dialysis patients had significantly lower MoCA and AVLT scores (including learning memory, short recall memory, and delayed recall memory) (all p < 0.001). They also showed exaggerated orthostatic systolic blood pressure reductions (all p