Preliminary validation and clinical meaning of the cutaneous assessment tool in juvenile dermatomyositis
Preliminary validation and clinical meaning of the cutaneous assessment tool in juvenile dermatomyositis
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DOI：
10.1002/art.23340
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发表时间：
2008-02-15
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影响因子：
--
通讯作者：
Rider, Lisa G.
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文献类型：
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作者：
Huber, Adam M.;Dugan, Elizabeth M.;Rider, Lisa G.
客观的。为评估青少年皮肌炎（DM）皮肤表现的新工具皮肤评估工具（CAT）提供初步验证，并探讨CAT评分的临床意义。方法。患有青少年 DM 的儿童 (n = 113) 在基线时和 7-9 个月后 (n = 94) 进行了评估。对 CAT 的内部一致性、冗余性、结构有效性和响应性进行了检查。确定了与顺序全球评估相对应的 CAT 分数。结果。对于≥ 10% 的患者存在活动性病变，项目总相关性范围为 0.27-0.67；项目-域和域-总相关性范围为 0.25-0.99。 CAT 活性评分的 Cronbach's alpha 值为 0.79，CAT 损伤评分的 Cronbach's alpha 值为 0.74。正如预测的那样，CAT 活动评分与总体疾病活动和皮肤疾病活动密切相关，与儿童肌炎评估量表呈中等相关，而 CAT 损伤评分与医生总体疾病和皮肤疾病损伤评分呈中等相关。 CAT 活性得分中位数为 1、7、13、18 和 31，分别对应于无、轻度、中度、重度和极重度皮肤病活动。 CAT 损伤中位数 0、1、2 和 5 分与相同的损伤描述相关（严重和极其严重的组合）。结论。 CAT 的初步验证显示出良好的内部一致性、非冗余性、良好的结构有效性和适当的响应性。 CAT 是一种针对青少年 DM 皮肤病的综合、半定量评估工具。
Objective. To provide preliminary validation of the Cutaneous Assessment Tool (CAT), a new tool to assess cutaneous manifestations of juvenile dermatomyositis (DM), and to explore the clinical meaning of CAT scores.Methods. Children with juvenile DM (n = 113) were assessed at baseline and 7-9 months later (n = 94). Internal consistency, redundancy, construct validity, and responsiveness of the CAT were examined. CAT scores corresponding to ordinal global assessments were determined.Results. Item-total correlations ranged from 0.27-0.67 for activity lesions present in >= 10% of patients; item-domain and domain-total correlations ranged from 0.25-0.99. Cronbach's alpha was 0.79 for the CAT activity score and 0.74 for the CAT damage score. As predicted, the CAT activity score correlated strongly with both global disease activity and skin disease activity and moderately with the Childhood Myositis Assessment Scale, whereas the CAT damage score correlated moderately with the physician global disease and skin disease damage scores. Median CAT activity scores of 1, 7, 13, 18, and 31 corresponded to absent, mild, moderate, severe, and extremely severe skin disease activity, respectively. Median CAT damage scores of 0, 1, 2, and 5 correlated with the same descriptions of damage (severe and extremely severe combined).Conclusion. Preliminary validation of the CAT demonstrated good internal consistency, nonredundancy, good construct validity, and appropriate responsiveness. The CAT is a comprehensive, semiquantitative assessment tool for skin disease in juvenile DM.