Increased serum osteopontin levels in autistic children: Relation to the disease severity
Increased serum osteopontin levels in autistic children: Relation to the disease severity
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DOI：
10.1016/j.bbi.2011.04.006
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发表时间：
2011-10-01
影响因子：
15.1
通讯作者：
Mostafa, Gehan A.
中科院分区：
文献类型：
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作者：
AL-ayadhi, Laila Y.;Mostafa, Gehan A.
脑自身免疫可能在孤独症发病中起一定作用。骨桥蛋白是一种促炎细胞因子，在多种自身免疫性神经炎性疾病中发挥重要作用。骨桥蛋白诱导T辅助细胞17淋巴细胞产生IL-17，T辅助细胞17淋巴细胞是自身免疫性疾病发病机制中的关键参与者。抗骨桥蛋白治疗通过减少IL-17的产生来降低一些自身免疫性神经炎性疾病的临床严重程度。我们是第一个测量血清骨桥蛋白水平，通过ELISA，在42名自闭症儿童相比，42名健康匹配的儿童。采用儿童孤独症评定量表（汽车）评估孤独症患者血清骨桥蛋白水平与孤独症严重程度的关系。孤独症患儿血清骨桥蛋白水平显著高于正常对照组（P < 0.001）。80.95%（34/42）的孤独症患儿血清骨桥蛋白水平升高。重度孤独症患儿血清骨桥蛋白水平显著高于轻中度孤独症患儿（P = 0.02）。孤独症患者血清骨桥蛋白水平与汽车呈正相关（P = 0.007）。结论：孤独症患儿血清骨桥蛋白水平升高，且与孤独症的严重程度显著相关。进一步的大规模研究是必要的，以阐明骨桥蛋白在自闭症中的致病作用，并调查其与IL-17和脑特异性自身抗体的关系，这些抗体是这些患者自身免疫的指标。还应研究抗骨桥蛋白抗体在改善自闭症表现中的治疗作用。(C)2011 Elsevier Inc. All rights reserved.
Autoimmunity to brain may play an etiopathogenic role in autism. Osteopontin is a pro-inflammatory cytokine that has been shown to play an important role in various autoimmune neuroinflammatory diseases. Osteopontin induces IL-17 production by T-helper 17 lymphocytes, the key players in the pathogenesis of autoimmune disorders. Anti-osteopontin treatment reduces the clinical severity of some autoimmune neuroinflammatory diseases by reducing IL-17 production. We are the first to measure serum osteopontin levels, by ELISA, in 42 autistic children in comparison to 42 healthy-matched children. The relationship between serum osteopontin levels and the severity of autism, which was assessed by using the Childhood Autism Rating Scale (CARS), was also studied. Autistic children had significantly higher serum osteopontin levels than healthy controls (P < 0.001). Increased serum osteopontin levels were found in 80.95% (34/42) of autistic children. Children with severe autism had significantly higher serum osteopontin levels than patients with mild to moderate autism (P = 0.02). Moreover, serum osteopontin levels of autistic patients had significant positive correlations with CARS (P = 0.007). In conclusions, serum osteopontin levels were increased in many autistic children and they were significantly correlated to the severity of autism. Further wide-scale studies are warranted to shed light on the etiopathogenic role of osteopontin in autism and to investigate its relation to IL-17 and brain-specific auto-antibodies, which are indicators of autoimmunity, in these patients. The therapeutic role of anti-osteopontin antibodies in amelioration of autistic manifestations should also be studied. (C) 2011 Elsevier Inc. All rights reserved.