VASOPRESSIN OXYTOCIN IN CEREBROSPINAL-FLUID OF SCHIZOPHRENIC-PATIENTS AND NORMAL CONTROLS
VASOPRESSIN OXYTOCIN IN CEREBROSPINAL-FLUID OF SCHIZOPHRENIC-PATIENTS AND NORMAL CONTROLS
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DOI：
10.1016/0306-4530(85)90056-3
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发表时间：
1985-01-01
影响因子：
3.7
通讯作者：
GATTAZ, WF
中科院分区：
文献类型：
--
作者：
BECKMANN, H;LANG, RE;GATTAZ, WF
抗利尿激素和催产素似乎与动物的学习和记忆过程有关，可能也与人类有关。这些肽似乎有相反的作用，在抗利尿激素改善记忆过程和催产素产生遗忘的效果。这些神经肽分别在接受和未接受抗精神病药物治疗的精神分裂症患者（丁苯酮和吩噻嗪）、精神健康对照者和未接受抗精神病药物治疗的患者的脑脊液中测定。抗利尿激素浓度在精神分裂症患者和对照组之间无显著差异。抗精神病药物治疗对抗利尿激素浓度无影响。所有精神分裂症患者的催产素浓度都增加了，接受神经痉挛治疗的患者的催产素浓度更高。抗精神病药治疗3周后催产素浓度升高。药物诱导的催产素浓度升高可能对抗精神病药物治疗的精神分裂症患者临床观察到的遗忘综合征和衰弱有重要意义。
Vasopressin and oxytocin seem to be involved in the processes of learning and memory in animals and probably in man. These peptides appear to have opposite effects in that vasopressin improves memory processes and oxytocin produces amnestic effects. These neuropeptides were measured in the CSF of schizophrenic patients with and without neuroleptic treatment [butyrophenone and phenothiazine] psychiatrically healthy controls and drug-free patients before and after 3 wk of neuroleptic treatment. There were no significant differences in vasopressin concentrations between schizophrenics and controls. No influence of neuroleptic treatment on vasopressin concentrations was detected. Concentrations of oxytocin were increased in all schizophrenic patients and were higher in those receiving neurolepic treatment. Oxytocin concentrations increased after 3 wk of neuroleptic treatment. Drug-induced increase of oxytocin concentrations may be of significance in the clinically observed amnestic syndromes and debilitation in schizophrenics treated with neuroleptics.