Low Urine Vascular Endothelial Growth Factor Levels Are Associated with Mechanical Ventilation, Bronchopulmonary Dysplasia and Retinopathy of Prematurity
Low Urine Vascular Endothelial Growth Factor Levels Are Associated with Mechanical Ventilation, Bronchopulmonary Dysplasia and Retinopathy of Prematurity
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DOI：
10.1159/000351040
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发表时间：
2013-01-01
期刊：
影响因子：
2.5
通讯作者：
Van Marter, Linda J.
中科院分区：
文献类型：
--
作者：
Levesque, Bernadette M.;Kalish, Leslie A.;Van Marter, Linda J.
背景资料：器官特异性血管内皮生长因子（VEGF）的表达下降，在支气管肺发育不良（BPD）和早产儿视网膜病变（ROP）的发病过程中，几个星期前，任何疾病可以诊断。早期测量器官特异性组织VEGF水平可能有助于识别这些疾病的高风险婴儿，但在临床上不可行。尿VEGF易于检测，可用于多种疾病的早期诊断。目的：我们的目的是评估在出生后第一个月测量的尿VEGF水平与随后的BPD或ROP诊断的相关性，并确定各种婴儿特征是否影响尿VEGF水平。方法：106名出生于
Background: Organ-specific vascular endothelial growth factor (VEGF) expression is decreased during the pathogenesis of bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) several weeks before either disease can be diagnosed. Early measurement of organ-specific tissue VEGF levels might allow identification of infants at high risk for these diseases, but is not clinically feasible. Urine VEGF is easily measured and useful in early diagnosis of several diseases. Objectives: Our aims were to assess the correlation of urine VEGF levels measured in the first postnatal month with subsequent BPD or ROP diagnosis and to determine whether various infant characteristics influence urine VEGF levels. Methods: 106 subjects born at