Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C
Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C
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DOI：
10.1016/j.jhep.2005.02.044
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发表时间：
2005-08-01
影响因子：
25.7
通讯作者：
Chen, DS
中科院分区：
文献类型：
--
作者：
Liu, CJ;Chen, PJ;Chen, DS
背景/目的：脂联素诱导胰岛素敏感性并调节炎症反应。因此，我们研究了脂联素在慢性丙型肝炎病毒（HCV）感染与胰岛素抵抗内在联系的患者中的意义。方法：我们分析了95例未经治疗的台湾慢性丙型肝炎患者抗病毒治疗前后血清脂联素水平与临床、病毒学和组织学结果的相关性。结果：基线时，95例患者中有14例（15%）肥胖，26例（27%）患有2型糖尿病。57例患者感染HCV基因型1和38与基因型2。分别有44例（46%）和69例（73%）出现脂肪变性和门静脉周围纤维化。在多因素分析中，男性、胰岛素抵抗、高HCV载量和基因2型与血清脂联素水平降低显著相关。相反，脂联素受体的肝内基因表达在基因型2比基因型1更高。血清脂联素水平与其他临床或组织学参数无关。结论：脂联素与丙型肝炎病毒因子在血清和肝组织水平均存在相关性。脂联素、胰岛素抵抗和慢性HCV感染之间的相互作用值得进一步研究。(c)2005年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background/Aims: Adiponectin induces insulin sensitivity and modulates inflammatory responses. We thus studied the implications of adiponectin in patients with chronic hepatitis C virus (HCV) infection inherently linked to insulin resistance.Methods: We analyzed the association of serum adiponectin levels with clinical, virologic, and histologic findings in 95 naive Taiwanese patients with chronic hepatitis C before and after antiviral therapy.Results: At baseline, 14 (15%) of the 95 patients were obese and 26 (27%) had type 2 diabetes mellitus. Fifty-seven patients were infected with HCV genotype 1 and 38 with genotype 2. Steatosis and periportal fibrosis was present in 44 (46%) and 69 (73%), respectively. In multivariate analysis, to male gender, insulin resistance, high HCV load and genotype 2 were significantly associated with a lower serum adiponectin level. In contrast, intrahepatic gene expression of adiponectin receptors was higher in genotype 2 compared with genotype 1. Serum adiponectin level did not correlate with other clinical or histologic parameters. After treatment, change of steatosis also did not correlate with the change of adiponectin level (P=0.61).Conclusions: Adiponectin correlated with hepatitis C viral factors at both serum and liver tissue levels. The interactions among adiponectin, insulin resistance and chromic HCV infection merit further studies. (c) 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.