Effects of GABAergic drugs in vivo on high-affinity choline uptake in vitro in mouse hippocampal synaptosomes.
Effects of GABAergic drugs in vivo on high-affinity choline uptake in vitro in mouse hippocampal synaptosomes.
复制标题
体内 GABA 能药物对小鼠海马突触体体外高亲和力胆碱摄取的影响。
DOI:
10.1111/j.1471-4159.1986.tb13107.x
复制
发表时间:
1986
影响因子:
4.7
通讯作者:
Richter,JA
中科院分区:
文献类型:
--
作者:
Miller,JA;Richter,JA
The effects of several γ‐aminobutyric acid (GABA)‐ergic drugs on sodium‐dependent high‐affinity choline uptake (HACU) were investigated in the hippocampus. HACU was measured in vitro after in vivo administration of the drug to mice. HACU was inhibited by those drugs that enhance GABA transmission. The convulsant 3‐mercaptopropionic acid, which decreases GABA levels, stimulated HACU. From these results and previous find ings, it appears that GABA mediates a tonic inhibitory effect on the septal‐hippocampal cholinergic system.
登录
查看更多内容
影响因子:
4.7
作者:
A. M. Goldberg;R. Mccaman
通讯作者:
R. Mccaman
影响因子:
5.6
作者:
A. Raines;G. J. Blake;Bernice Richardson;Mark B. Gilbert
通讯作者:
Mark B. Gilbert
DOI:
10.1016/s0031-6989(75)80032-4
发表时间:
1975
期刊:
Pharmacological research communications
影响因子:
--
作者:
M. Trabucchi;D. Cheney;G. Racagni;E. Costa
通讯作者:
E. Costa
影响因子:
64.8
作者:
P. Kessler;R. Marchbanks
通讯作者:
R. Marchbanks
DOI:
--
发表时间:
1982
期刊:
The Journal of pharmacology and experimental therapeutics
影响因子:
--
作者:
Richter,JA;Gormley,JM
通讯作者:
Gormley,JM