Evaluation of the X-ray distribution of a syringe-needle type proton-induced X-ray source by Geant4 simulation
Evaluation of the X-ray distribution of a syringe-needle type proton-induced X-ray source by Geant4 simulation
复制标题
Geant4模拟评估注射针式质子感生X射线源的X射线分布
DOI：
10.1002/xrs.2785
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发表时间：
2017
影响因子：
1.2
通讯作者：
Oguri Y.
中科院分区：
文献类型：
--
作者：
Hu Y.;Fukuda H.;Oguri Y.
基于加速器的注射器针型质子诱导X射线源是作者在2013年提出的前列腺癌近距离放射治疗的替代方案，其剂量分布受到许多因素的影响，如针的结构和入射质子束的条件。在本文中，作为评估剂量分布的一种方法，我们提出了一个Geant4模拟来研究入射质子束条件对X射线发射光谱和分布的影响，使用实验测量的质子束发射度作为输入数据。结果表明，光束不对准的影响是显著的，证实了该方法的有效性。期望通过改进该方法，能够明确影响X射线分布的其他因素，从而最终优化这些因素，为组织中任意大小和形状的肿瘤设计特殊的剂量分布。版权所有©2017 John Wiley & Sons， Ltd
The accelerator‐based syringe needle‐type proton‐induced X‐ray source, which was proposed by the authors in 2013 as an alternative for prostate cancer brachytherapy, has an essential issue in that its dose distribution is affected by many factors, such as the structure of the needle and incident proton beam conditions. In this paper, as a method of evaluating dose distribution, we propose a Geant4 simulation to study the effect of the incident proton beam condition on the spectrum and distribution of X‐ray emission, using experimentally measured proton beam emittance as input data. The results showed that the effect of beam misalignment was significant and confirmed the effectiveness of this method. It is expected that improving this method will clarify the other factors that affect X‐ray distribution, so that finally, we can optimize such factors in designing a special dose distribution for the irradiation of tumors of arbitrary size and shape in the tissue. Copyright © 2017 John Wiley & Sons, Ltd.