YOKUKANSAN, A TRADITIONAL JAPANESE MEDICINE, AMELIORATES MEMORY DISTURBANCE AND ABNORMAL SOCIAL INTERACTION WITH ANTI-AGGREGATION EFFECT OF CEREBRAL AMYLOID β PROTEINS IN AMYLOID PRECURSOR PROTEIN TRANSGENIC MICE
YOKUKANSAN, A TRADITIONAL JAPANESE MEDICINE, AMELIORATES MEMORY DISTURBANCE AND ABNORMAL SOCIAL INTERACTION WITH ANTI-AGGREGATION EFFECT OF CEREBRAL AMYLOID β PROTEINS IN AMYLOID PRECURSOR PROTEIN TRANSGENIC MICE
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DOI：
10.1016/j.neuroscience.2011.01.064
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发表时间：
2011-04-28
期刊：
影响因子：
3.3
通讯作者：
Yaegashi, N.
中科院分区：
文献类型：
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作者：
Fujiwara, H.;Takayama, S.;Yaegashi, N.
淀粉样β蛋白(Aβ)的沉积是阿尔茨海默病(AD)脑内一贯的病理特征。因此，抑制AB在大脑中的聚集是开发AD疾病修饰药物的一种有吸引力的治疗和预防策略。体外研究表明，日本传统药物Yokukansan(YKS)以浓度依赖的方式抑制Aβ聚集。一项体内研究表明，养肾散和钩藤(Uncaria Hook，UH)是养肾散的组成部分，可以防止大脑Aβ的蓄积。YKS还能改善淀粉样前体蛋白转基因小鼠的记忆障碍和异常社交行为，如增加攻击行为和减少社交行为。这些结果表明，益康散可能是一种预防和/或治疗AD的有效的新型治疗剂，这可能归因于UH。(C)2011年IBRO。爱思唯尔有限公司出版。保留所有权利。
The deposition of amyloid beta protein (A beta) is a consistent pathological hallmark of Alzheimer's disease (AD) brains. Therefore, inhibition of AB aggregation in the brain is an attractive therapeutic and preventive strategy in the development of disease-modifying drugs for AD. An in vitro study demonstrated that yokukansan (YKS), a traditional Japanese medicine, inhibited A beta aggregation in a concentration-dependent manner. An in vivo study demonstrated that YKS and Uncaria hook (UH), a constituent of YKS, prevented the accumulation of cerebral A beta. YKS also improved the memory disturbance and abnormal social interaction such as increased aggressive behavior and decreased social behavior in amyloid precursor protein transgenic mice. These results suggest that YKS is likely to be a potent and novel therapeutic agent to prevent and/or treat AD, and that this may be attributed to UH. (c) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.