Proton and Phosphorous MR Spectroscopy in Squamous Cell Carcinomas of the Head and Neck
Proton and Phosphorous MR Spectroscopy in Squamous Cell Carcinomas of the Head and Neck
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DOI：
10.1016/j.acra.2009.06.001
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发表时间：
2009-11-01
影响因子：
4.8
通讯作者：
Poptani, Harish
中科院分区：
文献类型：
--
作者：
Chawla, Sanjeev;Kim, Sungheon;Poptani, Harish
理由和目标。磷磁共振波谱（P-31 MRS）已被用于评估和预测头颈部鳞状细胞癌（HNSCC）的治疗反应。几项研究也显示了质子MRS（H-1 MRS）在评估HNSCC缓解方面的潜力。鉴于与在临床环境中进行P-31 MRS相关的固有局限性，进行本研究以探讨H-1 MRS是否可以在HNSCC.Materials和Methods中提供相似或互补的代谢信息。15例HNSCC患者接受了治疗前磁共振成像。H-1 MRS和P-31 MRS均对这些患者转移性淋巴结的活性实体部分进行。计算H-1 MRS上观察到的总胆碱（tCho）和未抑制水的峰面积以及P-31 MRS上的磷酸单酯（PME）和β-核苷酸三磷酸（β-NTP）。采用Pearson相关系数对tCho/water和PME/beta-NTP比值进行相关分析。在所有患者中，转移性淋巴结在T2加权像上呈高信号，在T1加权像上呈低信号，信号强度不一。所有患者的转移淋巴结在H-1 MRS上均观察到tCho的显著共振，在P-31 MRS上观察到PME的共振。tCho/water和PME/beta-NTP之间存在中度相关性（0.31）（P > .05）。tCho的H-1 MRS中涉及的生化途径可能与头颈部癌的P-31 MRS中观察到的磷脂代谢物不同，因此这两种MRS技术可能彼此互补。
Rationale and Objectives. Phosphorous magnetic resonance spectroscopy (P-31 MRS) has been used to evaluate and predict treatment response in squamous cell carcinoma of the head and neck (HNSCC). Several studies have also shown the potential of proton MRS (H-1 MRS) in assessing response in HNSCC. In view of the inherent limitations associated with performing P-31 MRS in clinical settings, the current study was performed to explore whether H-1 MRS could provide similar or complementary metabolic information in HNSCC.Materials and Methods. Fifteen patients with HNSCC underwent pretreatment magnetic resonance imaging. Both H-1 MRS and P-31 MRS were performed on viable solid parts of the metastatic lymph nodes of these patients. Peak areas of total choline (tCho) and unsuppressed water as observed on H-1 MRS and phosphomonoester (PME) and beta-nucleotide triphosphate (beta-NTP) on P-31 MRS were computed. Pearson's correlation coefficient was used to correlate the tCho/water and PME/beta-NTP ratios.Results. In all patients, the metastatic nodes appeared hyperintense on T2-weighted images and hypointense on T1-weighted images with variable signal intensity. A prominent resonance of tCho on H-1 MRS and a resonance of PME on P-31 MRS from the metastatic nodes of all patients were observed. A moderate correlation of 0.31 was observed between tCho/water and PME/beta-NTP (P > .05).Conclusions. The biochemical pathways involved in H-1 MRS of tCho may be different from the phospholipid metabolites seen on P-31 MRS of head and neck cancers, and thus the two MRS techniques may be complementary to each other.