SITES AND NATURE OF PROTEIN ANABOLISM STIMULATED BY TESTOSTERONE PROPIONATE IN THE RAT
SITES AND NATURE OF PROTEIN ANABOLISM STIMULATED BY TESTOSTERONE PROPIONATE IN THE RAT
复制标题
DOI：
10.1152/ajplegacy.1950.163.2.332
复制
发表时间：
1950-01-01
影响因子：
--
通讯作者：
BARTLETT, MN
中科院分区：
文献类型：
--
作者：
KOCHAKIAN, CD;ROBERTSON, E;BARTLETT, MN
去势成年大鼠进入体内。平衡和Injd。与丙酸睾丸酮一起沉积在胴体、精囊和前列腺、肝脏和肾脏中的蛋白质。然而，如果通过增加剂量或延长处理时间来增加处理强度，则尸体不仅开始损失脂肪，而且还开始损失蛋白质，这些蛋白质显然主要转移到附属性器官，并且在较小程度上，这些器官的肾脏继续生长。此外，如果大鼠具有相对较高的胴体脂肪含量，雄激素导致迅速降低到正常水平。上述效应发生在去势大鼠和自由进食的正常大鼠中。此外，雄激素在注射60天后引起去势大鼠食欲增加。但在正常大鼠中没有。骨骼肌（腓肠肌），肝脏，肾脏和精囊和前列腺的定性和定量氨基酸组成没有改变雄激素。此外，每个组织的氨基酸组成非常相似。连续13天注射1mg.丙酸睾丸酮日数与对照组相同。总氨基酸和尿中氨基酸的纸层析分配没有显着变化，由于雄激素。提出了雄激素对肿瘤作用机制的假说。
Castrated adult rats brought into body wt. equilibrium and injd. with testosterone propionate deposited protein in the carcass, seminal vesicles and prostates, liver and kidney. If, however, the intensity of treatment either by increased dosage or duration of treatment was increased, then the carcass began to lose not only fat but also protein which apparently was diverted to primarily the accessory sex organs and at a smaller extent the kidneys for these organs continued to grow. Furthermore, if the rats had a relatively high carcass fat content, the androgen caused a rapid reduction to the normal level. The above effect occurred in castrated and also normal rats fed ad libitum. Moreover, the androgen produced an increase in appetite of the castrated rats after 60 days of injn. but not in the normal rats. The qualitative and quantitative amino acid composition of the skeletal (gastrocnemius) muscle, liver, kidney and seminal vesicles and prostate were not changed by the androgen. Furthermore, the amino acid composition of each tissue was very similar. The total protein, non-protein N and amino acid N of the plasma of rats injected for 13 days with 1 mg./day of testosterone propionate were identical to those of control rats. The total amino acid and the partition of the urinary amino acids by paper chromatography showed no marked changes due to the androgen. An hypothesis for the mechanism of action of androgens on tumors is presented.