Taurospongins B and C, new acetylenic fatty acid derivatives possessing a taurine amide residue from a marine sponge of the family Spongiidae
Taurospongins B and C, new acetylenic fatty acid derivatives possessing a taurine amide residue from a marine sponge of the family Spongiidae
复制标题
DOI：
10.1039/c3ra47796g
复制
发表时间：
2014-02
期刊：
影响因子：
3.9
通讯作者：
T. Kubota;Haruna Suzuki;Azusa Takahashi-Nakaguchi;J. Fromont;T. Gonoi;J. Kobayashi
中科院分区：
文献类型：
--
作者：
T. Kubota;Haruna Suzuki;Azusa Takahashi-Nakaguchi;J. Fromont;T. Gonoi;J. Kobayashi
从冲绳海绵科海绵中分离得到两个新的含牛磺酸酰胺残基的炔属脂肪酸衍生物，即牛磺海绵素B（1）和C（2）。根据化合物1和2的波谱数据，特别是2DNMR和FABMS/MS数据，确定了化合物1和2的结构。用化学方法确定了化合物1和2的绝对构型。牛海绵素C（2）对新生隐球菌有抑制作用。
Two new acetylenic fatty acid derivatives possessing a taurine amide residue, taurospongins B (1) and C (2), have been isolated from an Okinawan marine sponge of the family Spongiidae. The gross structures of 1 and 2 were elucidated on the basis of their spectral data, especially 2D NMR and FABMS/MS data. The absolute configurations for 1 and 2 were established by chemical means. Taurospongin C (2) showed inhibitory activity against Cryptococcus neoformans.