Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID
Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID
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DOI：
10.1101/gad.300475.117
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发表时间：
2019-08-01
影响因子：
10.5
通讯作者：
Snel, Berend
中科院分区：
文献类型：
--
作者：
Antonova, Simona, V;Boeren, Jeffrey;Snel, Berend
基础转录因子TFIID是RNA聚合酶ii依赖性转录的中心。人类TFIID具有染色质读取器、dna结合域和蛋白质相互作用表面。14个TFIID tata结合蛋白（TBP）相关因子（TAF）亚基组装成与spt - ada - gcn5乙酰转移酶（SAGA）共激活子共享亚基的完整复合物。在这里，我们讨论了TFIID的结构和功能演变及其与SAGA的差异。我们的同源树和结构域分析揭示了表观遗传读取器的动态增益和损失，TAF1和TAF4的植物特异性功能，TAF2中的heat2样重复，以及重要的是，TFIID和SAGA的前leca起源。TFIID的进化体现了真核生物谱系中转录复合物的动态可塑性。
The basal transcription factor TFIID is central for RNA polymerase II-dependent transcription. Human TFIID is endowed with chromatin reader and DNA-binding domains and protein interaction surfaces. Fourteen TFIID TATA-binding protein (TBP)-associated factor (TAF) subunits assemble into the holocomplex, which shares subunits with the Spt-Ada-Gcn5-acetyltransferase (SAGA) coactivator. Here, we discuss the structural and functional evolution of TFIID and its divergence from SAGA. Our orthologous tree and domain analyses reveal dynamic gains and losses of epigenetic readers, plant-specific functions of TAF1 and TAF4, the HEAT2-like repeat in TAF2, and, importantly, the pre-LECA origin of TFIID and SAGA. TFIID evolution exemplifies the dynamic plasticity in transcription complexes in the eukaryotic lineage.