POLYGENIC CONTROL OF SUSCEPTIBILITY TO MURINE SYSTEMIC LUPUS-ERYTHEMATOSUS
POLYGENIC CONTROL OF SUSCEPTIBILITY TO MURINE SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1016/1074-7613(94)90100-7
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发表时间：
1994-06-01
期刊：
影响因子：
32.4
通讯作者：
WAKELAND, EK
中科院分区：
文献类型：
--
作者：
MOREL, L;RUDOFSKY, UH;WAKELAND, EK
用新开发的系统性红斑狼疮易感近交系NZM/Aeg2410杂交，分析了对肾小球肾炎(GN)的敏感性和抗dsDNA自身抗体的产生。用区间作图法分析了系统性红斑狼疮与C57BL/6回交的遗传方式及易感基因的数目和位置。在第1、4和7号染色体上发现了3个含有强隐性GN易感基因的染色体区间，每个区间含有几个潜在的候选基因。H-2的杂合性也被发现与GN的易感性有很强的相关性，这与先前在NZB/NZW亲本株模型中的发现一致。Logistic回归分析表明，每个易感等位基因都独立地解释了GN易感性的一个组成部分，在该模型系统中，易感性是遗传的阈值遗传易感性。
Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were analyzed by interval mapping in a backcross with C57BL/6. Three chromosomal intervals containing strong recessive GN susceptibility alleles were identified on chromosomes 1, 4, and 7, each containing several potentially interesting candidate genes. Heterozygosity at H-2 was also found to correlate strongly with GN susceptibility, consistent with previous findings in the NZB/NZW parental strain model. Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system.