Antibacterial alkaloids from chelidonium majus linn (papaveraceae) against clinical isolates of methicillin-resistant Staphylococcus aureus.
Antibacterial alkaloids from chelidonium majus linn (papaveraceae) against clinical isolates of methicillin-resistant Staphylococcus aureus.
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DOI：
10.18433/j3d30q
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发表时间：
2009-01
期刊：
影响因子：
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通讯作者：
G. Zuo;F. Meng;Xiao-yan Hao;Yunting Zhang;Gen-Chun Wang;G. Xu
中科院分区：
文献类型：
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作者：
G. Zuo;F. Meng;Xiao-yan Hao;Yunting Zhang;Gen-Chun Wang;G. Xu
目的研究白屈菜地上部分提取物和化合物的抑菌作用。(罂粟科)对抗耐甲氧西林金黄色葡萄球菌(MRSA)的临床菌株。方法采用大肉汤稀释法进行活性测定，并报告为MICS/MBCs。结果生物活性导向下的植物地上部分提取物(EtOAc)分离得到苯并菲类生物碱8-羟基二氢血根碱(HHS)和8-羟基二氢白藜芦碱(HHC)，它们对MRSA具有较强的抗菌活性。结论本文报道的8-羟基苯并[c]菲类生物碱的选择性抗菌活性为开发新的抗菌药物提供了可能，该药物可用于治疗造成全球医院感染的MRSA感染。
PURPOSE This study describes the antibacterial effect of extracts and compounds isolated from the aerial part of Chelidonium majus Linn. (Papaveraceae) acting against clinical strains of methicillin-resistant Staphylococcus aureus (MRSA). METHODS The activities were evaluated by using the macrobroth dilution method and reported as the MICs/MBCs. RESULTS Bioassay-guided fractionation of the most active extract from the aerial parts (EtOAc) led to the isolation of benzo[c]phenanthridine-type alkaloids 8-hydroxydihydrosanguinarine (hhS), 8-hydroxydihydrochelerythrine (hhC), which were potently active against MRSA strains. CONCLUSIONS The selective antibacterial activity reported in this paper for 8-hydroxylated benzo[c]phenanthridine-type alkaloids isolated from C.majus opens the possibility that they could be helpful for the developing of new antibacterial agents for treating the infection of MRSA which has created nosocomial problem worldwide.