CYTOGENETIC STUDIES IN 3 XENOGRAFTED NASOPHARYNGEAL CARCINOMAS
CYTOGENETIC STUDIES IN 3 XENOGRAFTED NASOPHARYNGEAL CARCINOMAS
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DOI：
10.1016/0165-4608(93)90141-8
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发表时间：
1993-03-01
影响因子：
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通讯作者：
TURSZ, T
中科院分区：
文献类型：
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作者：
BERNHEIM, A;ROUSSELET, G;TURSZ, T
本文报告了3例鼻咽癌移植瘤的细胞遗传学结果。其中1例(C15)几乎为二倍体，仅有1个等位染色体1Q，2个三体，X染色体缺失。另2个肿瘤C17和C19为亚二倍体，具有复杂的核型，但有一些变异。观察到1、3、8和17号染色体的非随机结构异常。强调了在C17中观察到的del(17)(p11-12)与最近在该肿瘤中显示的P53的两个等位基因丢失之间的相关性。
Cytogenetics results of three xenografted nasopharyngeal carcinomas (NPC) are reported. One (C15) was almost diploid and had only an isochromosome 1q, trisomy 2, and loss of chromosome X. The two other tumors, C17 and C19, were hypodiploid and had complex karyotypes with some variations. Nonrandom structural abnormalities of chromosomes 1, 3, 8, and 17 were observed. A correlation between a del(17)(p11-12) observed in C17 and loss of both alleles of p53 recently shown in this tumor is emphasized.