Neutropenia induced by systemic infusion of chemotactic factors.
Neutropenia induced by systemic infusion of chemotactic factors.
复制标题
全身输注趋化因子引起的中性粒细胞减少症。
作者：
J. O’Flaherty;H. Showell;P. Ward
自体血浆，当暴露在补体激活剂产生白细胞趋化活性，导致一过性中性粒细胞减少后，输注给兔。胰酶消化的人C5和从酵母多糖激活的人血清中分离出来的趋化片段也可以诱导兔的一过性中性粒细胞减少，化学活性的合成三肽也是如此。在每种情况下，诱导中性粒细胞减少的活性与趋化活性是平行的。因此，中性粒细胞减少的诱导活性和趋化活性似乎与中性粒细胞的生理反应有关。在体内，白细胞的边集和/或凝集可能是这种中性粒细胞减少的现象的基础。
Autologous plasma, when exposed to complement-activating agents that generate leukotactic activity, induces transient neutropenia after infusion into rabbits. Trypsinized human C5 as well as the chemotactic fragment isolated from zymosan-activated human serum also induces transient neutropenia in rabbits, as do chemotactically active synthetic tripeptides. In each instance the neutropenia-inducing activity parallels the chemotactic activity. Thus, neutropenia-inducing activity and chemotactic activity seem to be related physiologic responses of neutrophils. In vivo margination and/or agglutination of leukocytes may underlie this phenomenon of neutropenia.