Observation of treated iris neovascularization by swept-source-based en-face anterior-segment optical coherence tomography angiography
Observation of treated iris neovascularization by swept-source-based en-face anterior-segment optical coherence tomography angiography
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DOI：
10.1038/s41598-019-46514-z
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发表时间：
2019-07-16
影响因子：
4.6
通讯作者：
Nishida, Kohji
中科院分区：
文献类型：
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作者：
Shiozaki, Daiki;Sakimoto, Susumu;Nishida, Kohji
我们在抗血管内皮生长因子（VEGF）治疗后使用正面眼前节光学相干断层扫描血管造影（AS-OCTA）评估虹膜新生血管（INV）的消退情况。在抗 VEGF 治疗前后连续检查了 7 只患有 INV 的眼睛，所有 AS-OCTA 扫描均使用带有眼前节镜片适配器的扫源 OCTA 系统获得。还进行了裂隙灯显微镜摄影和前吲哚菁绿血管造影。对 AS-OCTA 图像上的血管密度、血管腔隙性和分形维数进行了定量分析。 AS-OCTA 将 INV 可视化为瞳孔边缘周围的信号，这与裂隙灯显微镜确认的脉管系统相对应。注射抗VEGF药物后，AS-OCTA观察到所有眼睛的INV消退（100%）。抗VEGF治疗后血管密度显着降低，血管腔隙显着增加。这项试点研究证明了 AS-OCTA 不仅能够检测 INV，还能评估 INV。需要进一步研究来改进描绘虹膜脉管系统的算法以减少伪影。
We evaluated regression of iris neovascularization (INV) using en-face anterior-segment optical coherence tomography angiography (AS-OCTA) after anti-vascular endothelial growth factor (VEGF) therapy. Seven consecutive eyes with INV were examined before and after anti-VEGF therapy, and all AS-OCTA scans were obtained using a swept-source OCTA system with an anterior-segment lens adapter. Slit-lamp microscopy photography and anterior indocyanine green angiography also were performed. Quantitative analyses of the vascular density, vascular lacunarity, and fractal dimension on AS-OCTA images were performed. AS-OCTA visualized the INV as signals around the pupillary margin, which corresponded to the vasculature confirmed by slit-lamp microscopy. After anti-VEGF drug injection, regression of INV was observed by AS-OCTA in all eyes (100%). The vascular density decreased and vascular lacunarity increased significantly after anti-VEGF therapy. This pilot study demonstrated the ability of AS-OCTA not only to detect but also to evaluate INV. Further study is warranted to improve the algorithm for delineating the iris vasculature to decrease artifacts.