Links between three chronic and age-related diseases, osteoarthritis, periodontitis, and osteoporosis, in a wild mammal (moose) population
Links between three chronic and age-related diseases, osteoarthritis, periodontitis, and osteoporosis, in a wild mammal (moose) population
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野生哺乳动物（驼鹿）种群中三种慢性和年龄相关疾病（骨关节炎、牙周炎和骨质疏松症）之间的联系
DOI：
10.1016/j.joca.2023.11.016
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发表时间：
2023
影响因子：
7
通讯作者：
Peterson, Rolf O.
中科院分区：
文献类型：
--
作者：
Hoy, Sarah R.;Vucetich, John A.;Vucetich, Leah M.;Hindelang, Mary;Huebner, Janet L.;Kraus, Virginia B.;Peterson, Rolf O.
骨关节炎、牙周炎和骨质疏松症是与年龄有关的慢性疾病，对全世界数百万人产生不利影响。由于这些疾病构成了重大的全球公共卫生挑战，因此迫切需要更好地了解这些疾病之间的相互关联。我们的目的是记录每种疾病的年龄和性别特异性患病率，并评估野生哺乳动物三种疾病之间的相互关系（驼鹿，Alces alces）种群。方法我们检查了自然死亡的驼鹿的骨骼，并记录了骨关节炎的严重程度（通常在臀部和最低椎骨上观察到），骨质疏松症（颅骨上观察到的骨质疏松性病变）和牙周炎（上颌骨和下颌骨上观察到的）。ResultsPeriodontitis与驼鹿严重骨关节炎和骨质疏松性病变的患病率较高相关。我们没有发现任何证据表明，驼鹿与骨关节炎病变或多或少可能表现出骨关节炎或严重骨关节炎的迹象。骨关节炎，牙周炎和牙周炎病变的患病率是男性比femines.ConclusionsOur结果是一致的假设，即细菌病原体引起牙周炎是骨关节炎和骨质疏松症的危险因素。它们也与以下假设一致，即有时在人类中观察到的骨关节炎和骨质疏松症之间的负相关性可能受到共同风险因素的影响，例如肥胖，吸烟或饮酒，这些因素在驼鹿中不存在。这些结果共同提供了关于三种疾病的见解，这些疾病预计将在未来变得更加普遍，并造成巨大的社会经济负担。
ObjectiveOsteoarthritis, periodontitis and osteoporosis are chronic, age-related diseases which adversely impact millions of people worldwide. Because these diseases pose a major global public health challenge, there is an urgent need to better understand how these diseases are interrelated. Our objective was to document the age and sex-specific prevalence of each disease and assess interrelationships among the three diseases in a wild mammal (moose,Alces alces) population.MethodsWe examined the bones of moose dying from natural causes and recorded the severity of osteoarthritis (typically observed on the hip and lowest vertebrae), osteoporosis (osteoporotic lesions observed on the skull) and periodontitis (observed on maxilla and mandibles).ResultsPeriodontitis was associated with a greater prevalence of both severe osteoarthritis and osteoporotic lesions in moose. We found no evidence to suggest that moose with osteoporotic lesions were more or less likely to exhibit signs of osteoarthritis or severe osteoarthritis. The prevalence of osteoarthritis, periodontitis and osteoporotic lesions was greater among males than for females.ConclusionsOur results were consistent with the hypothesis that bacterial pathogens causing periodontitis are a risk factor for osteoarthritis and osteoporosis. They are also consistent with the hypothesis that the inverse association between osteoarthritis and osteoporosis sometimes observed in humans may be influenced by shared risk factors, such as obesity, smoking or alcohol consumption, which are absent in moose. Together these results provide insights about three diseases which are expected to become more prevalent in the future and that cause substantial socio-economic burdens.