Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade.
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade.
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DOI：
10.1126/science.8066448
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发表时间：
1994-08
期刊：
影响因子：
56.9
通讯作者：
Diana L Sylvestre;Jeffrey V. Ravetch
中科院分区：
文献类型：
--
作者：
Diana L Sylvestre;Jeffrey V. Ravetch
抗体-抗原复合物启动炎症反应，并且是组织损伤的发病机制的核心。用Fc受体表达缺陷的鼠品系重新研究了这种免疫病理学级联反应的经典模型Arthus反应。尽管对其他刺激的炎症反应正常，但对免疫复合物的炎症反应明显减弱。这些结果表明，免疫复合物触发的炎症是由细胞结合的Fc受体引发的，然后被细胞介质和活化的补体放大。这些结果重新定义了炎症级联反应，并可能为免疫损伤的研究和治疗提供其他方法。
Antibody-antigen complexes initiate the inflammatory response and are central to the pathogenesis of tissue injury. The classical model for this immunopathological cascade, the Arthus reaction, was reinvestigated with a murine strain deficient in Fc receptor expression. Despite normal inflammatory responses to other stimuli, the inflammatory response to immune complexes was markedly attenuated. These results suggest that immune complex-triggered inflammation is initiated by cell bound Fc receptors and is then amplified by cellular mediators and activated complement. These results redefine the inflammatory cascade and may offer other approaches for the study and treatment of immunological injury.