Combined fibrinogen concentration and neutrophil-lymphocyte ratio as a prognostic marker of gastric cancer
Combined fibrinogen concentration and neutrophil-lymphocyte ratio as a prognostic marker of gastric cancer
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DOI：
10.3892/ol.2015.4049
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发表时间：
2016-02-01
期刊：
影响因子：
2.9
通讯作者：
Natsugoe, Shoji
中科院分区：
文献类型：
--
作者：
Arigami, Takaaki;Uenosono, Yoshikazu;Natsugoe, Shoji
某些早期胃癌患者会死于复发性疾病和癌症相关并发症。复发的关键原因很难确定，因为能够预测胃癌肿瘤特性的临床血液标志物有限。本研究调查了胃癌患者血液标本中的纤维蛋白原浓度和中性粒细胞-淋巴细胞比值（NLR），并评估了纤维蛋白原浓度与NLR（CFS-NLR）联合作为胃癌预后标志物的临床适用性。本研究由 275 名胃癌患者组成，分为三组：高纤维蛋白原血症（>= 305 mg/dl）和高 NLR（>= 2.34；CFS-NLR 2 组）；患有高纤维蛋白原血症或高 NLR 的患者（CFS-NLR 1 组）；或均无异常者（CFS-NLR 0组）。 CFS-NLR与肿瘤浸润深度、淋巴结转移、淋巴管侵犯及肿瘤分期显着相关（P
Certain patients with early gastric cancer succumb to recurrent disease and cancer-associated complications. The key cause of recurrence is challenging to determine, since clinical blood markers that are able to predict the tumor properties of gastric cancer are limited. The present study investigated the fibrinogen concentration and neutrophil-lymphocyte ratio (NLR) in blood specimens from patients with gastric cancer, and assessed the clinical applicability of combining the fibrinogen concentration with the NLR (CFS-NLR) as a prognostic marker of gastric cancer. The present study consisted of 275 patients with gastric cancer, who were divided into three groups: Those possessing hyperfibrinogenemia (>= 305 mg/dl) and a high NLR (>= 2.34; CFS-NLR 2 group); those possessing either hyperfibrinogenemia or a high NLR (CFS-NLR 1 group); or those that possessed neither abnormality (CFS-NLR 0 group). The CFS-NLR was significantly associated with the depth of tumor invasion, lymph node metastasis, lymphovascular invasion and tumor stage (P