Immune infiltration in renal cell carcinoma
Immune infiltration in renal cell carcinoma
复制标题
肾细胞癌的免疫浸润
DOI：
10.1111/cas.13996
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发表时间：
2019-05-01
期刊：
影响因子：
5.7
通讯作者：
Zeng, Zhu
中科院分区：
文献类型：
--
作者：
Zhang, Shichao;Zhang, Erdong;Zeng, Zhu
肿瘤的免疫浸润与肾细胞癌（RCC）的临床结局密切相关。肿瘤浸润免疫细胞（TIIC）调节癌症进展，是有吸引力的治疗靶点。本研究的目的是确定肾细胞癌中TIIC的组成，并进一步揭示TIIC的独立预后价值。CIBERSORT是一种成熟的算法，基于891种肿瘤的基因表达谱，估计了22种免疫细胞类型的比例。使用考克斯回归来评估TIIC和免疫检查点调节剂与总生存期（OS）的关联。我们发现CD 8 + T细胞与嫌色细胞癌（KICH）的OS延长相关（风险比[HR]=0.09，95%置信区间[CI] 0.01 - 0.53; P=0.03）。调节性T细胞比例越高，预后越差（HR=1.59，95%CI 1.23-.06; P
Immune infiltration of tumors is closely associated with clinical outcome in renal cell carcinoma (RCC). Tumor-infiltrating immune cells (TIICs) regulate cancer progression and are appealing therapeutic targets. The purpose of this study was to determine the composition of TIICs in RCC and further reveal the independent prognostic values of TIICs. CIBERSORT, an established algorithm, was applied to estimate the proportions of 22 immune cell types based on gene expression profiles of 891 tumors. Cox regression was used to evaluate the association of TIICs and immune checkpoint modulators with overall survival (OS). We found that CD8+ T cells were associated with prolonged OS (hazard ratio [HR]=0.09, 95% confidence interval [CI].01-.53; P=0.03) in chromophobe carcinoma (KICH). A higher proportion of regulatory T cells was associated with a worse outcome (HR=1.59, 95% CI 1.23-.06; P