Emerging Roles of Neuronal Extracellular Vesicles at the Synapse.
Emerging Roles of Neuronal Extracellular Vesicles at the Synapse.
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DOI：
10.1177/10738584231160521
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发表时间：
2023-03
期刊：
影响因子：
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通讯作者：
Ashley J Mason;C. Deppmann;B. Winckler
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文献类型：
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作者：
Ashley J Mason;C. Deppmann;B. Winckler
细胞外囊泡（EVs）由大多数（如果不是全部的话）细胞类型分泌，并涉及全身的短距离和长距离信号传导。电动汽车也从神经元分泌，代表了一个新兴的神经元通信平台。要理解EV信号传导给受体神经元和神经胶质的功能含义，就需要理解受体细胞中涉及EV生物发生、装载、分泌、摄取和信号转导的细胞生物学。在这里，我们回顾了EV生物学的这些主要问题，同时强调了神经系统中最近的新见解和例子，例如调节受体神经元的突触功能或形态发生。
Extracellular vesicles (EVs) are secreted from most, if not all, cell types and are implicated in short- and long-distance signaling throughout the body. EVs are also secreted from neurons and represent an emergent neuronal communication platform. Understanding the functional implications of EV signaling to recipient neurons and glia requires understanding the cell biology involved in EV biogenesis, cargo loading, secretion, uptake, and signal transduction in the recipient cell. Here we review these major questions of EV biology while highlighting recent new insights and examples within the nervous system, such as modulating synaptic function or morphogenesis in recipient neurons.