High Neutrophil Numbers in Human Carotid Atherosclerotic Plaques Are Associated With Characteristics of Rupture-Prone Lesions
High Neutrophil Numbers in Human Carotid Atherosclerotic Plaques Are Associated With Characteristics of Rupture-Prone Lesions
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DOI：
10.1161/atvbaha.110.209296
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发表时间：
2010-09-01
影响因子：
8.7
通讯作者：
de Kleijn, Dominique P. V.
中科院分区：
文献类型：
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作者：
Ionita, Mihaela G.;van den Borne, Pleunie;de Kleijn, Dominique P. V.
方法和结果-中性粒细胞是在动脉粥样硬化斑块破裂或侵蚀部位发现的具有组织破坏能力的炎性细胞。人颈动脉粥样硬化斑块中中性粒细胞浸润的证据不足，其与斑块形态的关系尚未得到描述。对一组355个人颈动脉斑块进行中性粒细胞标记物CD 66 b染色。在具有大脂质核心、高巨噬细胞数目、低胶原含量和平滑肌细胞数目的斑块中发现高中性粒细胞数目。高中性粒细胞数与高白细胞介素8相关（P
Objective-To score the number of plaque neutrophils and relate the score to plaque morphology and inflammatory status.Methods and Results-Neutrophils are inflammatory cells with tissue destruction capabilities that have been found at the site of an atherosclerotic plaque rupture or erosion. Poor evidence exists for neutrophil infiltration in human carotid atherosclerotic plaques, and its association with plaque morphology has not yet been described. A set of 355 human carotid plaques was stained for the neutrophil marker CD66b. High neutrophil numbers were found in plaques with a large lipid core, high macrophage numbers, and low collagen amount and smooth muscle cell numbers. High neutrophil numbers were associated with high interleukin 8 (P