Reduced size of the amygdala in individuals with 47,XXY and 47,XXX Karyotypes
Reduced size of the amygdala in individuals with 47,XXY and 47,XXX Karyotypes
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DOI：
10.1002/ajmg.10154
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发表时间：
2002-01-08
期刊：
影响因子：
--
通讯作者：
Reiss, AL
中科院分区：
文献类型：
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作者：
Patwardhan, AJ;Brown, WE;Reiss, AL
在精神分裂症患者的细胞遗传学筛查研究中发现了超过47，XXX和47，XXY核型，这支持了性染色体非整倍体(SCA)男性和女性患精神疾病的风险增加。内侧颞叶结构，包括杏仁核和海马体，被认为与人类情绪和行为异常以及精神分裂症的神经生物学有关。本研究主要研究男性和女性SCA患者内侧颞叶结构体积的变化。利用未经选择的SCA和高分辨率磁共振成像(NMI)受试者的出生队列，我们研究了额外的X染色体对杏仁核和海马体形态的神经解剖学后果。测量了10名47，XXY受试者、10名47，XXX受试者和20名整倍体对照组的局部脑体积和总脑体积。与对照组相比，携带47，XX-Y基因的男性患者杏仁核体积显著减少，而携带47，XXX基因的女性患者杏仁核体积减少不明显。与同性对照组相比，两组的海马体体积都得到了保留。对SCA个体的纵向研究表明，与对照人群相比，47，XXY男性中轻度精神病理和行为障碍的发生率增加，而47，XXX女性中更明显的精神疾病的发生率更高。X染色体异常个体杏仁核体积的改变可能为这些发现提供神经解剖学基础。(C)2001年Wiley-Liss，Inc.
The excess of 47,XXX and 47,XXY karyotypes found in cytogenetic screening studies of individuals with schizophrenia has given support for an increased risk of psychiatric illness among men and women with sex chromosomal aneuploidy (SCA). Mesial temporal lobe structures, including the amygdala and hippocampus, are thought to be associated with abnormalities of mood and behavior in humans and in the neurobiology of schizophrenia. This study focuses on variations in volumes of mesial temporal lobe structures in men and women with SCA. Utilizing an unselected birth cohort of subjects with SCA and high-resolution magnetic resonance imaging (NMI), we investigated the neuroanatomical consequences of a supernumerary X chromosome on the morphology of the amygdala and hippocampus. Regional and total brain volumes were measured in 10 subjects with 47,XXY, 10 subjects with 47,XXX, and 20 euploid controls. Amygdala volumes were significantly reduced in men with 47,XX-Y, compared to control men, while the decrease in women with 47,XXX was not as pronounced. Hippocampus volumes were preserved in both groups, compared to same-gender controls. Longitudinal studies of SCA individuals have shown an increased incidence of mild psychopathology and behavioral dysfunction in men with 47,XXY and more overt psychiatric illness in women with 47,XXX, compared to control populations. The alteration in amygdala volumes in individuals with a supernumerary X chromosome may provide a neuroanatomic basis for these findings. (C) 2001 Wiley-Liss, Inc.