Synthesis, Structures, and CO Release Capacity of a Family of Water-Soluble PhotoCORMs: Assessment of the Biocompatibility and Their Phototoxicity toward Human Breast Cancer Cells
Synthesis, Structures, and CO Release Capacity of a Family of Water-Soluble PhotoCORMs: Assessment of the Biocompatibility and Their Phototoxicity toward Human Breast Cancer Cells
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DOI：
10.1021/acs.inorgchem.6b02623
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发表时间：
2017-02-06
影响因子：
4.6
通讯作者：
Mascharak, Pradip K.
中科院分区：
文献类型：
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作者：
Chakraborty, Indranil;Carrington, Samantha J.;Mascharak, Pradip K.
由2-（吡啶基）苯并噻唑（pbt）和1,10-菲罗啉（phen）衍生的两种锰(I)羰基配合物在低功率宽带可见光照射下释放一氧化碳（CO）。[Mn(CO)(3)(pbt) (PTA)] CF3SO3（1，其中PTA = 1,3,5-三氮杂-7-磷金刚烷）的CO光释放伴随着几乎非荧光预辐照1在400 nm左右出现强荧光。而[Mn(CO)(3)(phen)(PTA)]-CF3SO3(2)在相同的实验条件下，在长时间光照下则没有出现这种现象。合成了两种类似的铼(I)配合物[Re(CO)(3)(pbt)(PTA)]CF3SO3(3)和[Re-(CO)(3)(phen)(PTA)]CF3SO3(4)，并对其进行了表征，比较了它们与锰同系物的光性质。配合物3和4在低功率紫外光照射下表现出适度的CO释放。所有这四种配合物在厌氧/好氧水介质中都是高度可溶的，并且在黑暗条件下也相当稳定。固有发光的铼络合物3被用来证明MDA-MB-231（人类乳腺癌）细胞对这些类型的化合物的细胞内化，而两种生物相容性的锰(I)络合物（1和2）被用来评估这些恶性细胞在CO递送后的细胞存活率。
Two manganese(I) carbonyl complexes derived from 2-(pyridyl)benzothiazole (pbt) and 1,10-phenanthroline (phen) release carbon monoxide (CO) under low-power broad-band visible-light illumination. CO photorelease from [Mn(CO)(3)(pbt) (PTA)] CF3SO3 (1, where PTA = 1,3,5-triaza-7-phosphaadamantane) is accompanied by an emergence of a strong fluorescence around 400 nm from almost nonfluorescent preirradiated 1. However, [Mn(CO)(3)(phen)(PTA)]-CF3SO3 (2) showed no such phenomenon upon prolonged illumination under similar experimental conditions. The two analogous rhenium(I) complexes, namely, [Re(CO)(3)(pbt)(PTA)]CF3SO3 (3) and [Re-(CO)(3)(phen)(PTA)]CF3SO3 (4), have also been synthesized and characterized to compare their photo properties with the manganese congeners. Complexes 3 and 4 exhibit moderate CO release upon irradiation with low-power UV light. All four complexes are highly soluble in anaerobic/aerobic aqueous media and are also considerably more stable when kept under dark conditions. The inherently luminescent rhenium complex 3 was utilized to demonstrate cellular internalization of these types of compounds by MDA-MB-231 (human breast cancer) cells, while the two biocompatible manganese(I) complexes (1 and 2) have been applied to assess the cell viability of these malignant cells upon CO delivery.