REACTIVITY TO NOVELTY DURING YOUTH AS A PREDICTIVE FACTOR OF COGNITIVE IMPAIRMENT IN THE ELDERLY - A LONGITUDINAL-STUDY IN RATS
REACTIVITY TO NOVELTY DURING YOUTH AS A PREDICTIVE FACTOR OF COGNITIVE IMPAIRMENT IN THE ELDERLY - A LONGITUDINAL-STUDY IN RATS
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DOI：
10.1016/0006-8993(94)90371-9
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发表时间：
1994-08-08
期刊：
影响因子：
2.9
通讯作者：
SIMON, H
中科院分区：
文献类型：
--
作者：
DELLU, F;MAYO, W;SIMON, H
对大鼠进行了某些行为特征的寿命研究。在环形走廊中反复测试动物对新奇事物的反应性以及认知能力的识别记忆任务。这些措施揭示了年轻受试者和老年受试者之间重要的个体差异。其中一些差异随着年龄的增长而出现（记忆缺陷），而另一些则消失（对新奇事物的高反应性）。此外，还发现年轻人对新奇事物的高反应性与老年人记忆识别缺陷之间存在关系。对新奇事物高反应的老鼠有与年龄相关的记忆障碍，而低反应的老鼠却没有。虽然连接这两种行为特征的生物学机制仍有待证明，但这项研究表明，与年龄相关的损伤可以通过生命早期可检测到的因素来预测。
A life-span study of certain behavioral traits was conducted in rats. Animals were repeatedly tested in a circular corridor for reactivity to novelty and in a recognition memory task for cognitive abilities. These measures revealed important inter-individual differences in young as well as in old subjects. Some of these differences appear with aging (memory deficits) and others disappear (high reactivity to novelty). Moreover, a relationship between high reactivity to novelty in youth and deficits in memory recognition in elderly was found. Rats that are high-responders to novelty had age-related memory impairments whereas the low-responder rats did not. While the biological mechanism linking these two behavioral traits remains to be demonstrated, this study shows that age-related impairments can be predicted by factors detectable early in life.