Ursolic Acid Derivatives from Bangladeshi Medicinal Plant, Sarauja roxburghii : Isolation and Cytotoxic Activity against A431 and C6 glioma Cell Lines
Ursolic Acid Derivatives from Bangladeshi Medicinal Plant, Sarauja roxburghii : Isolation and Cytotoxic Activity against A431 and C6 glioma Cell Lines
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来自孟加拉国药用植物 Sarauja roxburghii 的熊果酸衍生物：针对 A431 和 C6 神经胶质瘤细胞系的分离和细胞毒性活性
DOI：
10.1016/j.phytol.2011.04.019
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
K.Fukase
中科院分区：
文献类型：
--
作者：
K.Mazumder;E.R.O.Siwu;K.Tanaka;S.Nozaki;Y.Watanabe;K.Fukase
从孟加拉国药用植物--三白草（Saurauja roxburghii）的叶的甲醇提取物中分离得到熊烯型五环三萜，包括熊果酸、科罗索酸和一种新的熊烯型五环三萜，7，24-二羟基熊果酸。对C6大鼠胶质瘤细胞株和A431人表皮样癌细胞株进行细胞毒性试验。虽然它们具有相同的乌索烯型五环三萜核心结构，但萜结构上羟基的位置和数量显著影响活性和对细胞系的选择性。
Ursene-type pentacyclic triterpenes, including the ursolic acid, corosolic acid, and a new ursene-type pentacyclic triterpene, 7,24-dihydroxy ursolic acid, were isolated from the methanolic extract of the leaves of the Bangladeshi medicinal plant, Saurauja roxburghii, a higher plant indigenous to South East Asia and some part of North America. They were tested for the cytotoxicity against C6 rat glioma and A431 human epidermoid carcinoma cell lines. Although they have the same ursene-type pentacyclic triterpene core structure, the position and numbers of hydroxyl groups on the terpene structure significantly affected the activity and the selectivity to the cell lines.