Relation of sorting impairment to hippocampal damage in temporal lobe epilepsy
Relation of sorting impairment to hippocampal damage in temporal lobe epilepsy
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DOI：
10.1016/s0028-3932(00)00104-4
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发表时间：
2001-01-01
期刊：
影响因子：
2.6
通讯作者：
Giovagnoli, AR
中科院分区：
文献类型：
--
作者：
Giovagnoli, AR
为探讨海马区病变和记忆障碍在分类障碍中的作用，对112例左(n=65)或右(n=47)颞叶癫痫合并内侧或外侧病变的患者与53例左(n=30)或右额叶(n=23)癫痫患者进行比较。36例年龄、文化程度相近的健康受试者为对照组。采用改良的威斯康星卡片分类测验(MWCST)考察分类能力。使用双音节单词广度和词表学习的选择性回忆过程中的一致性长时提取来评估记忆。瑞文的有色递进矩阵和注意矩阵用于控制抽象推理和注意力。伴有左侧海马区硬化的左侧FLE患者和TLE患者在MWCST、短时记忆和单词学习方面均显著受损。有其他左侧海马区病变的TLE患者在MWCST上也有损害，尽管不是很明显。单项评分分析显示，42%的TLE患者合并左侧海马区硬化。有其他海马区损害的TLE患者14%、左侧FLE患者63%、右侧FLE患者30%在MWCST上受损。在左侧海马区硬化症患者中，MWCST评分与选择性提醒程序提供的学习评分和Raven‘s彩色递进矩阵评分相关，而在FLE患者中，MWCST评分与注意矩阵评分相关。这些结果表明，只有部分TLE患者，即那些海马区受损的患者，可能会在卡片分类上受到损害。这些TLE患者的分类能力受损可能是由于海马区功能参与形成联系或记录新信息。(C)2000爱思唯尔科学有限公司。保留所有权利。
One hundred and twelve patients with left (n = 65) or right (n = 47) temporal lobe epilepsy (TLE), associated with mesial or lateral temporal lobe lesion, were compared to 53 patients with left (n = 30) or right (n = 23) frontal lobe epilepsy (FLE), in order to explore the contributions of hippocampal lesions and of memory deficits to sorting impairment. Thirty-six healthy subjects of similar age and education were controls. The Modified Wisconsin Card Sorting Test (MWCST) was used to explore sorting ability. The two-syllable word span and consistent long-term retrieval from the selective reminding procedure for word-list learning were used to evaluate memory. Raven's Coloured Progressive Matrices and Attentive Matrices served to control for abstract reasoning and attention. Left FLE patients and TLE patients with left hippocampal sclerosis were significantly impaired on MWCST, short-term memory, and word learning. TLE patients with other left hippocampal lesions were also impaired on MWCST, although not significantly so. Analysis of individual scores showed that 42% of TLE patients with left hippocampal sclerosis. 14% of TLE patients with other hippocampal lesions, 63% of left FLE patients, and 30% of right FLE patients were impaired on the MWCST. In patients with left hippocampal sclerosis, MWCST score was associated with the learning score provided by the selective reminding procedure and Raven's Coloured Progressive Matrices score, whereas in FLE patients, MWCST score was associated with Attentive Matrices score. These results suggest that only some TLE patients, i.e, those with hippocampal damage, may be expected to be impaired on card sorting. The impaired sorting ability of these TLE patients may be due to involvement of the hippocampal function in forming associations or in registering new information. (C) 2000 Elsevier Science Ltd. All rights reserved.