Endothelial function in well-developed canine coronary collateral vessels.
Endothelial function in well-developed canine coronary collateral vessels.
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发育良好的犬冠状侧支血管的内皮功能。
DOI：
10.1152/ajpheart.1993.264.2.h567
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Bache,RJ
中科院分区：
文献类型：
--
作者：
Altman,J;Dulas,D;Pavek,T;Laxson,DD;Homans,DC;Bache,RJ
这项研究检查了冠状动脉侧支血流对内皮依赖性血管扩张剂的反应。在左冠状动脉前降支 (LAD) 栓塞闭塞后 4-6 个月内对 13 只狗进行了研究。侧支血流被确定为来自插管 LAD 的逆行血流的总和，并使用在逆行血流收集期间施用的微球来测量持续的组织血流。将激动剂引入左冠状动脉主干以到达左冠状动脉系统产生的侧支循环。内皮依赖性血管扩张剂乙酰胆碱和缓激肽分别导致侧支血流增加 21 +/- 7% 和 25 +/- 8%（每个 P < 0.05）。这与硝酸甘油产生的侧支血流增加 28 +/- 8% 没有什么不同。为了确定血管扩张剂前列腺素是否导致侧支血流增加，在用吲哚美辛（5 mg/kg iv）阻断环氧合酶后进行了研究。吲哚美辛导致基础条件下逆行血流减少 30 +/- 9%，但不会减弱乙酰胆碱、缓激肽或硝酸甘油产生的最大侧支血流速率。这些数据证明了发达的冠状动脉侧支循环中完整的内皮依赖性血管舒张机制。
This study examined responses of coronary collateral blood flow to endothelial-dependent vasodilators. Studies were performed in 13 dogs 4-6 mo after embolic occlusion of the left anterior descending coronary artery (LAD). Collateral flow was determined as the sum of retrograde flow from the cannulated LAD, and continuing tissue flow was measured with microspheres administered during the retrograde flow collection. Agonists were introduced into the left main coronary artery to reach collaterals arising from the left coronary arterial system. The endothelial-dependent vasodilators acetylcholine and bradykinin caused 21 +/- 7 and 25 +/- 8% increases of collateral flow, respectively (each P < 0.05). This was not different from the 28 +/- 8% increase in collateral flow produced by nitroglycerin. To determine whether vasodilator prostaglandins contributed to the increased collateral flow, studies were performed after cyclooxygenase blockade with indomethacin (5 mg/kg iv). Indomethacin caused a 30 +/- 9% decrease of retrograde flow during basal conditions but did not blunt the maximum collateral flow rates produced by acetylcholine, bradykinin, or nitroglycerin. These data demonstrate intact endothelial-dependent vasodilator mechanisms in the well-developed coronary collateral circulation.