THE CONTRIBUTIONS OF DISEASE-ACTIVITY, SLEEP PATTERNS, AND DEPRESSION TO FATIGUE IN SYSTEMIC LUPUS-ERYTHEMATOSUS - A PROPOSED MODEL
THE CONTRIBUTIONS OF DISEASE-ACTIVITY, SLEEP PATTERNS, AND DEPRESSION TO FATIGUE IN SYSTEMIC LUPUS-ERYTHEMATOSUS - A PROPOSED MODEL
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DOI：
10.1002/art.1780380617
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发表时间：
1995-06-01
影响因子：
--
通讯作者：
WINKEL, GH
中科院分区：
文献类型：
--
作者：
MCKINLEY, PS;OUELLETTE, SC;WINKEL, GH
目的：本研究从多个角度描述狼疮性疲劳，并引入一个多变量模型：睡眠问题和抑郁症，通过相互作用，作为介体，通过狼疮疾病活动增加疲劳。对48名系统性红斑狼疮（SLE）患者和27名普通人群的自我报告的睡眠模式、抑郁和疲劳进行了评估。结果：SLE组的总体疲劳程度高于对照组，疲劳的时间维度和情感维度比感觉维度和严重度维度更有差异，SLE组的睡眠潜伏期和总睡眠时间也更长，但抑郁程度不高。采用结构方程模型的一种形式--两阶段回归，支持了所提出的狼疮疲劳模型。结论：这些初步结果将疲劳描述为一种由多个因素引起的多维现象，他们建议疲劳治疗策略除了解决疾病活动外，还应解决介导过程，如睡眠和抑郁。
Objective, This study describes lupus fatigue multidimensionally and introduces a multivariate model: Sleep problems and depression, through reciprocal effects on each other, act as mediators through which lupus disease activity increases fatigue,Methods. Self-reported sleep patterns, depression, and fatigue were assessed in 48 women with systemic lupus erythematosus (SLE) and 27 women from the general population. Rheumatologists rated current lupus disease activity,Results, The SLE group reported greater overall fatigue than did the controls, Temporal and affective dimensions of fatigue were more differentiating than sensory or severity dimensions, The SLE group also reported longer sleep latency and total sleep time, but not higher depression, Using 2-stage regression, a form of structural equation modeling, the proposed lupus fatigue model was supported,Conclusion, These preliminary results describe fatigue as a multidimensional phenomenon arising out of several contributing factors, They suggest that fatigue treatment strategies should address mediating processes such as sleep and depression, in addition to disease activity.