Large-scale evaluation of the current level of polybrominated diphenyl ethers (PBDEs) in breast milk from 13 regions of Japan
Large-scale evaluation of the current level of polybrominated diphenyl ethers (PBDEs) in breast milk from 13 regions of Japan
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DOI：
10.1016/j.chemosphere.2005.09.067
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发表时间：
2006-04-01
期刊：
影响因子：
8.8
通讯作者：
Ikeda, M
中科院分区：
文献类型：
--
作者：
Eslami, B;Koizumi, A;Ikeda, M
2004年对来自日本13个地区(北海道、秋田、宫城、东京、岐阜市、福井市、京都、兵库市、和歌山市、岛根县、山口市、高知县和冲绳县)的105份母乳样本进行了多溴联苯醚(PBDEs)检测。用气相色谱/质谱仪(GC/MS)测定了6种同系物(BDE-28、BDE-47、BDE-99、BDE-100、BDE-153和BDE-154)。多溴联苯醚总水平为0.01~23.0 ng/g脂肪(几何平均数，1.34 ng/g脂肪)。BDE-47(GM，0.66 ng/g脂肪，59%的Sigma PBDE)是母乳中含量最丰富的同系物，99%的样本中都有BDE-47的检测。日本北部的多溴联苯醚总水平高于其他地区。我们分析了职业、年龄、吸烟状况、饮酒和分娩次数对总多溴联苯醚水平的影响。这些因素与多溴二苯醚的水平均无显著关联。目前的研究表明，日本目前接触多溴二苯醚的水平低于美国或瑞典。各地区多溴二苯醚的GMS(ng/g脂肪)(GSD，几何标准差)和中位数(ng/g脂肪)如下：北海道2.70(1.70)，2.74；秋田4.49(2.19)，5.44；宫城1.77(4.37)1.11；东京1.39(2.09)，1.63；岐阜市2.83(4.79)，2.23；福井1.05(2.34)，1.18。-京都1.31(2.95)，1.33；兵库1.02(2.69)，0.88：若山1.33(3.80)，1.70：岛根0.83(2.51)，0.66；山口1.74(2.82)，1.76；高知0.50(2.69)，0.74；冲绳1.91(2.75)，1.22。这是日本首次对母乳中当前的多溴二苯醚水平进行大规模研究。(C)2005爱思唯尔有限公司。保留所有权利。
Polybrominated diphenyl ethers (PBDEs) were measured in 2004 in 105 breast milk samples collected from 13 regions of Japan (Hokkaido, Akita, Miyagi, Tokyo, Gifu, Fukui, Kyoto, Hyogo, Wakayama, Shimane, Yamaguchi, Kochi and Okinawa). Six congeners (BDE-28, BDE-47, BDE-99, BDE-100, BDE-153 and BDE-154) were determined by gas chromatography/mass spectrometry (GC/MS). Total PBDE levels ranged from 0.01 to 23.0 ng/g lipid (geometric mean (GM), 1.34 ng/g lipid). BDE-47 (GM, 0.66 ng/g lipid, 59% of Sigma PBDE) was the most abundant congener present in breast milk and was detected in 99% of the samples. Total PBDE levels were higher in northern Japan than in other regions. We analyzed the effects of occupation, age, smoking status, alcohol consumption and number of deliveries on total PBDE levels. None of these factors were significantly associated with the level of PBDEs. The present study revealed that the current level of exposure to PBDEs in Japan is lower than that in the USA or Sweden. GMs (ng/g lipid) (GSD, geometric standard deviation) and medians (ng/g lipid) of PBDE levels in each district are as follows: Hokkaido 2.70 (1.70), 2.74; Akita 4.49 (2.19), 5.44; Miyagi 1.77 (4.37) 1.11; Tokyo 1.39 (2.09), 1.63, Gifu 2.83 (4.79), 2.23; Fukui 1.05 (2.34), 1.18.- Kyoto 1.31 (2.95), 1.33; Hyogo 1.02 (2.69), 0.88: Wakayama 1.33 (3.80), 1.70: Shimane 0.83 (2.51), 0.66; Yamaguchi 1.74 (2.82), 1.76; Kochi 0.50 (2.69), 0.74 and Okinawa 1.91 (2.75), 1.22. This is the first large-scale study of current PBDE levels in breast milk in Japan. (c) 2005 Elsevier Ltd. All rights reserved.