Differences in the cellular composition of small versus large uterine fibroids
Differences in the cellular composition of small versus large uterine fibroids
复制标题
小子宫肌瘤与大子宫肌瘤细胞组成的差异。
DOI：
10.1530/rep-16-0216
复制
发表时间：
2016-11-01
期刊：
影响因子：
3.8
通讯作者：
Rogers, Peter A. W.
中科院分区：
文献类型：
--
作者：
Holdsworth-Carson, Sarah J.;Zhao, Dong;Rogers, Peter A. W.
子宫肌瘤是从单个细胞克隆而来的；然而，尽管是单克隆性的，构成子宫肌瘤的细胞表型是异质性的，主要由平滑肌细胞(SMC)和成纤维细胞组成。这提出了一个问题，即在肌瘤发育过程中克隆细胞分化何时发生，以及这些信息是否提供了导致症状大小的肌瘤可能的生长过程调控机制的线索？本研究用免疫组织化学方法(IHC)研究了子宫肌瘤细胞成分的差异。应用组织芯片(n=21例子宫切除术)对大子宫肌瘤和正常子宫肌层进行了研究。小肌瘤的调查(
Uterine fibroids are clonally derived from a single cell; however, despite being monoclonal, the cellular phenotypes that make up uterine fibroids are heterogeneous consisting of predominantly smooth muscle cells (SMC) and fibroblasts. This raises the question as to when clonal cell differentiation occurs during fibroid development, and does this information provide clues about possible mechanisms regulating the growth process that leads to fibroids of symptom-causing size? This study investigated the differences in the cellular composition of fibroids by immunohistochemistry (IHC). A tissue microarray (n = 21 hysterectomy cases) was used for the investigation of large uterine fibroids and normal myometrium. An investigation of small fibroids (