Cyclic pressure affects osteoblast functions pertinent to osteogenesis
Cyclic pressure affects osteoblast functions pertinent to osteogenesis
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DOI：
10.1114/1.1590663
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发表时间：
2003-09-01
影响因子：
3.8
通讯作者：
Bizios, R
中科院分区：
文献类型：
--
作者：
Nagatomi, J;Arulanandam, BR;Bizios, R
In an attempt to elucidate the cellular/molecular correlations between mechanical stimuli and new bone formation, the present in vitro study used a custom-made laboratory setup and examined the effects of cyclic pressure on select functions of osteoblasts pertinent to osteogenesis. The results demonstrated that, compared to controls (no pressure), mRNA expression for type-I collagen (the main constituent of the organic phase of bone) was enhanced when osteoblasts were exposed to cyclic pressure (10-40 kPa at 1.0 Hz) for 1 h daily for up to 19 consecutive days. In addition, compared to controls, both deposition of collagen and accumulation of calcium (one of the major components of the inorganic phase of bone) increased significantly (p
