Precision medicine in breast cancer: reality or utopia?
Precision medicine in breast cancer: reality or utopia?
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DOI：
10.1186/s12967-017-1239-z
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发表时间：
2017-06-17
影响因子：
7.4
通讯作者：
Ghiringhelli F
中科院分区：
文献类型：
--
作者：
Bettaieb A;Paul C;Plenchette S;Shan J;Chouchane L;Ghiringhelli F
许多癌症，包括乳腺癌，由于靶向治疗的发现，已经证明了预后和支持优势。这些新方法的出现标志着精准医学的兴起，从而改善了癌症的诊断、预后和治疗。精准医学考虑到患者及其肿瘤的分子和生物学特异性，这些特异性将影响医生决定的治疗。通过分子遗传学平台、高速测序仪的发展和这些数据的分析手段，可以进入这个新的医学时代。尽管在治疗包括乳腺癌在内的癌症方面取得了惊人的成果，但并非所有患者都能从这种新策略中受益。这似乎与许多基因突变有关，这些基因突变可能在不同患者之间或同一患者内不同。从技术和生物学的角度来看，它为研究提供了新的动力，使所有人都能获得精确医学的希望。
Many cancers, including breast cancer, have demonstrated prognosis and support advantages thanks to the discovery of targeted therapies. The advent of these new approaches marked the rise of precision medicine, which leads to improve the diagnosis, prognosis and treatment of cancer. Precision medicine takes into account the molecular and biological specificities of the patient and their tumors that will influence the treatment determined by physicians. This new era of medicine is accessible through molecular genetics platforms, the development of high-speed sequencers and means of analysis of these data. Despite the spectacular results in the treatment of cancers including breast cancer, described in this review, not all patients however can benefit from this new strategy. This seems to be related to the many genetic mutations, which may be different from one patient to another or within the same patient. It comes to give new impetus to the research—both from a technological and biological point of view—to make the hope of precision medicine accessible to all.