LncRNA-MM2P Identified as a Modulator of Macrophage M2 Polarization
LncRNA-MM2P Identified as a Modulator of Macrophage M2 Polarization
复制标题
LncRNA-MM2P 被鉴定为巨噬细胞 M2 极化的调节剂。
DOI：
10.1158/2326-6066.cir-18-0145
复制
发表时间：
2019-02-01
影响因子：
10.1
通讯作者：
Yang, Bo
中科院分区：
文献类型：
--
作者：
Cao, Ji;Dong, Rong;Yang, Bo
M2 polarization of macrophages is essential for their function in immunologic tolerance, which might promote tumorigenesis. However, the molecular mechanism behind the polarization process is not fully understood. Given that several lines of evidence have suggested that long noncoding RNAs (lncRNAs) could be involved in regulating immune cell differentiation and function, the current study aimed to identify the lncRNAs that specifically modulate M2 macrophage polarization. By utilizing a series of cell-based M2 macrophage polarization models, a total of 25 lncRNAs with altered expression were documented based on lncRNA microarray-based profiling assays. Among them, lncRNA-MM2P was the only lncRNA upregulated during M2 polarization but downregulated in M1 macrophages. Knockdown of lncRNA-MM2P blocked cytokine-driven M2 polarization of macrophages and weakened the angiogenesis- promoting feature of M2 macrophages by reducing phosphorylation on STAT6. Moreover, manipulating lncRNA-MM2P in macrophages impaired macrophage-mediated promotion of tumorigenesis, tumor growth in vivo, and tumor angiogenesis. Collectively, our study identifies lncRNA-MM2P as a modulator required for macrophage M2 polarization and uncovers its role in macrophage-promoted tumorigenesis.
