SAC3 may link nuclear protein export to cell cycle progression
SAC3 may link nuclear protein export to cell cycle progression
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DOI：
10.1073/pnas.050432997
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发表时间：
2000-03-28
影响因子：
11.1
通讯作者：
Corbett, AH
中科院分区：
文献类型：
--
作者：
Jones, AL;Quimby, BB;Corbett, AH
Selective movement of proteins between the nucleus and the cytoplasm is a regulatory mechanism exploited extensively by the eukaryotic cell. We have identified the evolutionarily conserved Sac3 protein, which was implicated previously in the regulation of mitosis [Bauer, A. & Kolling. R, (1996) J. cell Sci. 109, 1575-1583] as a novel mediator of nuclear protein export We show that Sac3p is localized to the nuclear pore, where it interacts with nucleoporins, Loss of SAC3 function results in a block in nuclear export of a nuclear export signal-containing reporter protein. Our results also demonstrate that SAC3 interacts genetically with the nuclear protein export factors Crm1p/Xpo1p and Yrb2p, Taken together, these data indicate a link between nuclear protein export and transition through the cell cycle.
