Plasma and salivary IgG subclasses in HIV type 1 infection: evidence of both transudation and local synthesis of IgG in parotid saliva.
Plasma and salivary IgG subclasses in HIV type 1 infection: evidence of both transudation and local synthesis of IgG in parotid saliva.
复制标题
HIV 1 型感染中的血浆和唾液 IgG 亚类：腮腺唾液中 IgG 渗出和局部合成的证据。
DOI：
10.1089/08892220050140973
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Jackson,S
中科院分区：
文献类型：
--
作者：
Wu,X;Jackson,S
在这项研究中，我们测量了 81 名 HIV-1 感染者和 30 名未感染者的血浆和唾液 IgG 亚类水平。 HIV-1感染者唾液IgG1升高，而唾液IgG2和IgG4降低。血浆抗 HIV-1 IgG 抗体水平较高的患者表现出较高的 CD4+ 细胞计数和较低的病毒载量。血浆中高水平的抗 HIV-1 IgG 抗体也与腮腺唾液中高水平的抗 HIV-1 IgG 抗体相关。通过比较唾液 IgG 与血浆 IgG 的 HIV-1 识别模式，我们确定血浆和唾液 IgG 抗体对 HIV-1 抗原的反应性既有相似之处，也有差异。本研究表明，HIV-1 感染会影响血浆和唾液 IgG，并提供证据证明腮腺唾液中 HIV-1 特异性 IgG 抗体的来源主要是从血浆渗出；然而，腮腺唾液中也会发生一些 IgG 的局部合成。
In this study we measured the levels of plasma and salivary IgG subclasses in 81 HIV-1-infected individuals and 30 uninfected controls. Salivary IgG1 was increased in HIV-1-infected patients, while salivary IgG2 and IgG4 were decreased. Patients with high levels of plasma anti-HIV-1 IgG antibodies presented a higher CD4+cell count and lower viral load. High levels of anti-HIV-1 IgG antibodies in plasma were also associated with high levels of anti-HIV-1 IgG antibodies in parotid saliva. In comparing the HIV-1 recognition patterns of salivary IgG with plasma IgG, we determined that plasma and salivary IgG antibodies had similarities as well as differences in their reactivity to HIV-1 antigens. The present study demonstrates that HIV-1 infection affects both plasma and salivary IgG and provides evidence that the origin of HIV-1-specific IgG antibodies in parotid saliva is primarily transudated from plasma; however, some local synthesis of IgG in parotid saliva also occurs.