Associations between fatty liver index and asymptomatic intracranial vertebrobasilar stenosis in Chinese population.
Associations between fatty liver index and asymptomatic intracranial vertebrobasilar stenosis in Chinese population.
复制标题
中国人群脂肪肝指数与无症状颅内椎基底动脉狭窄的相关性
DOI：
10.1371/journal.pone.0187502
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Dong C
中科院分区：
文献类型：
--
作者：
Qiu J;Zhou Z;Wang J;Wang Y;Liu C;Liu X;Xu Y;Yu L;Zhou H;Lin J;Guo Z;Dong C
代谢性疾病如2型糖尿病（T2 DM）和代谢综合征（MetS）已被认为是无症状性颅内椎基底动脉狭窄（IVBS）的重要危险因素。虽然脂肪肝指数（FLI）与这些疾病有显著相关性，但FLI与IVBS之间的关系尚不清楚。在本研究中，2368名参与者（30-75岁）从中国PMMJS前瞻性队列研究中招募。其中，2281名在基线时没有IVBS的人参加了6年的随访研究。根据基线特征进行横断面分析，结果显示FLI与IVBS患病率呈正相关。与FLI < 30组相比，30 ≤ FLI < 60组和FLI ≥ 60组IVBS的校正OR（95%CI）分别为2.07（1.18，3.62）和2.85（1.39，5.18）。在纵向分析中，结果显示，与FLI < 30的受试者相比，FLI ≥ 60的受试者发生无症状IVBS的风险增加[校正HR（95%CI）：1.65（1.05，2.60）]。此外，排除高血压、2型糖尿病和代谢综合征患者并没有改变FLI和无症状IVBS之间的相关性。因此，我们的研究结果表明，FLI升高是中国成人无症状IVBS的独立危险因素。
Metabolic diseases such as type 2 diabetes mellitus (T2DM) and metabolic syndromes (MetS) have been recognized as the important risk factors for asymptomatic intracranial vertebrobasilar stenosis (IVBS). Although fatty liver index (FLI) is significantly related with these diseases, the association between FLI and IVBS remains unclear. In the present study, 2368 participants (30–75 years) were recruited from a Chinese prospective cohort study of PMMJS. Amongst them, 2281 individuals who did not have IVBS at baseline were enrolled in the 6-year following-up study. In cross-sectional analysis based on the baseline characteristics, the results showed that FLI was positively related with IVBS prevalence. Compared to the participants with FLI < 30, the adjusted OR (95% CI) of IVBS was 2.07 (1.18, 3.62) and 2.85 (1.39, 5.18) in the groups of 30 ≤ FLI < 60 and FLI ≥ 60, respectively. In longitudinal analysis, the results showed that the participants with FLI ≥ 60 had an increased risk of asymptomatic IVBS compared to those with FLI < 30 [adjusted HR (95%CI): 1.65 (1.05, 2.60)]. Moreover, exclusion of persons with hypertension, T2DM and MetS did not alter the associations between FLI and asymptomatic IVBS. Therefore, our results suggest that elevated FLI is an independent risk factor for asymptomatic IVBS in Chinese adults.
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影响因子：
4.2
作者：
Cohen DE;Fisher EA
通讯作者：
Fisher EA
中国中老年人非酒精性脂肪肝脂肪肝指数的验证。
影响因子：
1.6
作者：
Huang X;Xu M;Chen Y;Peng K;Huang Y;Wang P;Ding L;Lin L;Xu Y;Chen Y;Lu J;Wang W;Bi Y;Ning G
通讯作者：
Ning G
影响因子：
25.7
作者：
Targher, Giovanni;Bertolini, Lorenzo;Bonora, Enzo
通讯作者：
Bonora, Enzo
影响因子：
8.3
作者：
Lutsep, HL;Barnwell, S;King, P
通讯作者：
King, P
影响因子：
5.1
作者：
Manne, Vignan;Saab, Sammy
通讯作者：
Saab, Sammy