Molecular pathways for cancer angioprevention
Molecular pathways for cancer angioprevention
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DOI：
10.1158/1078-0432.ccr-07-0069
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发表时间：
2007-08-01
影响因子：
11.5
通讯作者：
Ferrari, Nicoletta
中科院分区：
文献类型：
--
作者：
Albini, Adriana;Noonan, Douglas M.;Ferrari, Nicoletta
与心血管药物通过预防措施成功降低死亡率类似，癌症化学预防有可能显著降低肿瘤的发病率和死亡率。血管生成是一种被大多数有前途的癌症化学预防化合物抑制的事件，我们称之为“血管预防”。“在这里，我们回顾了内皮细胞中各种血管预防化合物靶向的信号通路。我们强调了不同的作用机制，这意味着联合血管预防方法可以进一步提高疗效，并转移到临床实践。
By analogy to the success of cardiovascular medicine in reducing mortality through preventive measures, cancer chemoprevention has the potential to significantly reduce incidence and mortality due to tumors. Angiogenesis is an event inhibited by most of the promising cancer chemoprevention compounds, a concept we termed "angioprevention." Here, we review the signaling pathways that are targeted by diverse angioprevention compounds in endothelial cells. We highlight diverse mechanisms of action, implying that combination angioprevention approaches could further improve efficacy and be transferred to clinical practice.