Histopathological features of canine distemper recently observed in Japan
Histopathological features of canine distemper recently observed in Japan
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DOI：
10.1016/s0021-9975(97)80057-6
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发表时间：
1997-05-01
影响因子：
0.8
通讯作者：
Kai, C
中科院分区：
文献类型：
--
作者：
Okita, M;Yanai, T;Kai, C
对来自日本中部地区和东京地区的 11 只患有犬瘟热 (CD) 的狗进行了检查。临床上，所有动物都存在呼吸系统和神经系统体征。组织病理学上，均显示出支气管肺炎和脱髓鞘性脑炎的特征性 CD 病变。然而，观察到胃肠道异常的一些差异。中部地区的四分之三的狗患有严重腹泻和胃肠炎，与粘膜上皮中存在大量嗜酸性包涵体有关。该地区剩下的一只狗出现呕吐，但没有腹泻，胃和肠粘膜也有一些上皮内包涵体。相比之下，来自东京地区的七只狗既没有表现出胃肠道症状，也没有出现胃或肠道上皮内包涵体。然而，CD病毒抗原的免疫组织化学检查显示，这7只狗的粘膜上皮细胞中有免疫反应产物，表明上皮细胞要么感染CD病毒的水平较低，要么感染细胞致病性较低的病毒。这些发现表明，就胃肠道组织的趋上皮性和细胞病变作用而言，本研究中的狗可能受到两种不同类型 CD 的影响。 (C) 1997 W.B.桑德斯有限公司。
Eleven dogs with canine distemper (CD) from the Chubu region of Japan and the Tokyo area were examined. Clinically, respiratory and neurological signs were present in all animals. Histopathologically, all showed characteristic CD lesions of bronchopneumonia and demyelinating encephalitis. However, some differences in gastrointestinal abnormalities were observed. Three out of four dogs from the Chubu region had severe diarrhoea and gastroenteritis, associated with numerous eosinophilic inclusion bodies in the mucosal epithelia. The remaining dog from this area showed vomiting, but not diarrhoea, and also had a number of intraepithelial inclusion bodies in the gastric and intestinal mucosa. In contrast, the seven dogs from the Tokyo area showed neither gastrointestinal symptoms nor intraepithelial inclusions in the stomach or intestine. Immunohistochemical examination for CD virus antigen, however, revealed that these seven dogs had immunoreactive products in the mucosal epithelia, suggesting that the epithelial cells had either a low level of infection with CD virus or were infected with a less cytopathogenic virus. These findings suggest that the dogs in this study were probably affected by two distinct types of CD, in terms of epitheliotropism and cytopathogenic effects on the gastrointestinal tissues. (C) 1997 W.B. Saunders Company Limited.