Regional lung perfusion:: Assessment with partially parallel three-dimensional MR imaging
Regional lung perfusion:: Assessment with partially parallel three-dimensional MR imaging
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DOI：
10.1148/radiol.2311030193
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发表时间：
2004-04-01
期刊：
影响因子：
19.7
通讯作者：
Kauczor, HU
中科院分区：
文献类型：
--
作者：
Fink, C;Puderbach, M;Kauczor, HU
目的：评价部分平行三维(3D)磁共振成像在评价健康志愿者和可疑肺癌或转移患者肺局部血流灌注中的作用。材料和方法：对7名健康志愿者和20名疑似肺癌或转移患者进行了部分平行三维梯度回波磁共振成像(快速低角度激发3D成像；重复时间毫秒/回波时间毫秒，1.9/0.8；翻转角度，40度；加速系数，2；校准参考k-空间线数目，24；视野，500×440 mm；矩阵，256×123；薄片厚度160 mm；间隔数32个；体素大小，3.6×2.0 x 5.0 mm(3)；采集时间1.5秒)。在志愿者中，3D MR灌注数据集被评估区域肺灌注的地形图和时间分布。以常规核素灌注显像为标准，计算MR灌注成像检测患者血流灌注异常的敏感性、特异性、准确性、阳性预测值和阴性预测值。观察者间和模式间的一致性采用K统计。结果：对志愿者肺血流灌注的地形图分析显示，在重力依赖的肺区，信噪比(SNR)高达327%。时间分析同样显示，重力依赖的肺区增强达到峰值的滞后时间要短得多。在患者中，灌注磁共振成像对检测灌注异常具有很高的敏感性(88%-94%)、特异性(100%)和准确性(90%-95%)。观察者间的一致性(kappa=0.86)非常好，而不同模式间的一致性(kappa=0.69-0.83)对于检测血流灌注缺陷很好到非常好。正常肺(14+/-7[SD])和灌注缺损组(7+/-4)的信噪比有显著差异(P<；0.0001)。结论：部分平行磁共振成像具有较高的时间和空间分辨率，可以评估局部肺灌注，对发现肺灌注异常具有较高的诊断准确率。(C)RSNA，2004年。
PURPOSE: To evaluate partially parallel three-dimensional (3D) magnetic resonance (MR) imaging for assessment of regional lung perfusion in healthy volunteers and patients suspected of having lung cancer or metastasis.MATERIALS AND METHODS: Seven healthy volunteers and 20 patients suspected of having lung cancer or metastasis were examined with 3D gradient-echo MR imaging with partially parallel image acquisitions (fast low-angle shot 3D imaging; repetition time msec/echo time msec, 1.9/0.8; flip angle, 40degrees; acceleration factor, two; number of reference k-space lines for calibration, 24; field of view, 500 x 440 mm; matrix, 256 X 123; slab thickness, 160 mm; number of partitions, 32; voxel size, 3.6 X 2.0 x 5.0 mm(3); acquisition time, 1.5 seconds) after administration of 0.1 mmol/kg of gadobenate dimeglumine. In volunteers, 3D MR perfusion data sets were assessed for topographic and temporal distribution of regional lung perfusion. Sensitivity, specificity, accuracy, and positive and negative predictive values for perfusion MR imaging for detecting perfusion abnormalities in patients were calculated, with conventional radionuclide perfusion scintigraphy as the standard of reference. Interobserver and intermodality agreement was determined by using K statistics.RESULTS: Topographic analysis of lung perfusion in volunteers revealed a significantly higher signal-to-noise ratio (SNR) of up to 327% in gravity-dependent lung areas. Temporal analysis similarly revealed much shorter lag time to peak enhancement in gravity-dependent lung areas. In patients, perfusion MR imaging achieved high sensitivity (88%-94%), specificity (100%), and accuracy (90%-95%) for detection of perfusion abnormalities. Interobserver agreement (kappa = 0.86) was very good and intermodality agreement (kappa = 0.69-0.83) was good to very good for detection of perfusion defects. A significant difference (P < .0001) in SNR was observed between normally perfused lung (14 +/- 7 [SD]) and perfusion defects (7 +/- 4) in patients.CONCLUSION: Partially parallel MR imaging with high spatial and temporal resolution allows assessment of regional lung perfusion and has high diagnostic accuracy for detecting perfusion abnormalities. (C) RSNA, 2004.