A TAIL WITHDRAWAL PROCEDURE FOR ASSESSING ANALGESIC ACTIVITY IN RHESUS-MONKEYS
A TAIL WITHDRAWAL PROCEDURE FOR ASSESSING ANALGESIC ACTIVITY IN RHESUS-MONKEYS
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DOI：
10.1016/0160-5402(86)90056-2
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发表时间：
1986-06-01
期刊：
影响因子：
--
通讯作者：
WOODS, JH
中科院分区：
文献类型：
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作者：
DYKSTRA, LA;WOODS, JH
恒河猴被限制在椅子上，它们的尾巴从椅子上自由悬挂，这样它们的尾巴就可以浸入热水瓶中。猴子的尾巴始终保持在38 - 40度。但在1-4秒内将它们从55 ℃水中取出。从55 ℃水中的缩尾时间在3小时内保持一致。吗啡使从55 ℃水中的缩尾时间呈剂量依赖性增加。C水，而戊巴比妥，氟哌啶醇，苯环己哌啶并没有增加尾部撤回lavonium，除非在剂量，产生显着的镇静。
Rhesus monkeys were restrained in chairs from which their tails hung free so that their tails could be immersed into a thermos of water. Monkeys consistently kept their tails in 38-40.degree. C water for at least 20 sec, but withdrew them from 55.degree.C water in 1-4 sec. Tail withdrawal latencies from 55.degree.C water remained consistent over a period of 3 hr. Morphine produced dose-dependent increases in tail withdrawal latencies from 55.degree. C water, whereas pentobarbital, haloperidol, and phencyclidine did not increase tail withdrawal latencies except at doses that produced marked sedation.