Assessing the stand-alone sensitivity of computer-aided detection with cancer cases from the Digital Mammographic Imaging Screening Trial.
Assessing the stand-alone sensitivity of computer-aided detection with cancer cases from the Digital Mammographic Imaging Screening Trial.
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DOI：
10.2214/ajr.11.7255
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Pisano E
中科院分区：
文献类型：
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作者：
Cole EB;Zhang Z;Marques HS;Nishikawa RM;Hendrick RE;Yaffe MJ;Padungchaichote W;Kuzmiak C;Chayakulkheeree J;Conant EF;Fajardo LL;Baum J;Gatsonis C;Pisano E
评估两种CADE系统应用于数字或屏幕胶片乳房X光检查时，在DMIST乳腺癌筛查人群中检测已知乳腺癌病例的敏感性和误检率。用iCAD Second Look(ICAD)和R2 ImageChecker(R2)两个CADE系统分析了DMIST提供的161例乳腺癌患者的屏幕胶片和数字化乳房X线片。三位经验丰富的乳房影像放射科医生审查了为每个可用癌症病例生成的CADE标记，记录了CADE标记的数量和位置，以及每个CADE标记位置是否与已知的癌症位置相对应。在本研究纳入的161例癌症病例中，DMIST阅读器对数字化乳腺摄影的敏感度为0.43(69/161，95%CI 0.35~0.51)，对胶片屏幕乳房摄影的敏感度为0.41(66/161，95%CI 0.33~0.49)。ICAD对数字化乳腺摄影的敏感性为0.74(119/16 1，95%CI 0.66~0.81)，对屏幕胶片摄影的敏感性为0.69(11 1/161，95%CI 0.61~0.76)，均显著高于DMIST研究的敏感性(p<；0.0001)。平均每例iCAD的假CADE标记数为2.57(SD 1.92)，屏幕-胶片钼靶摄影为3.06(SD 1.72)。R2对数字化乳腺摄影的敏感度为0.74(119/161，95%可信区间0.66~0.81)，对屏幕-胶片钼靶摄影的敏感度为0.60(97/161，95%可信区间0.52~0.68)，均显著高于DMIST研究敏感度(P<；0.0001)。平均每例R2的假CADE标记数为2.07(SD 1.57)，屏幕胶片摄影为1.52(SD 1.45)。我们的结果表明，在数字和屏幕胶片乳房X光片的解释中使用CADE可能会改善癌症检测。
To assess the sensitivities and false detection rates of two CADe systems when applied to digital or screen-film mammograms in detecting the known breast cancer cases from the DMIST breast cancer screening population. Available screen-film and digital mammograms of 161 breast cancer cases from DMIST were analyzed by two CADe systems, iCAD SecondLook (iCAD) and R2 ImageChecker (R2). Three experienced breast imaging radiologists reviewed the CADe marks generated for each available cancer case, recording the number and locations of CADe marks and whether each CADe mark location corresponded with the known location of the cancer. For the 161 cancer cases included in this study, the sensitivities of the DMIST reader without CAD were 0.43 (69/161, 95% CI 0.35 to 0.51) for digital and 0.41 (66/161, 95% CI 0.33 to 0.49) for film-screen mammography. The sensitivities of iCAD were 0.74 (119/161, 95% CI 0.66 to 0.81) for digital and 0.69 (111/161, 95% CI 0.61 to 0.76) for screen-film mammogram, both significantly higher than the DMIST study sensitivities (p< 0.0001 for both). The average number of false CADe marks per case of iCAD was 2.57 (SD 1.92) for digital and 3.06(SD 1.72) for screen-film mammography. The sensitivity of R2 was 0.74 (119/161, 95% CI 0.66 to 0.81) for digital, and 0.60 (97/161, 95% CI 0.52 to 0.68) for screen-film mammography, both significantly higher than the DMIST study sensitivities (p< 0.0001 for both). The average number of false CADe marks per case of R2 was 2.07 (SD 1.57) for digital and 1.52(SD 1.45) for screen-film mammogram. Our results suggest the use of CADe in interpretation of digital and screen-film mammograms could lead to improvements in cancer detection.